Interior shots of the Miami Herald office building were actually shot at the Miami Herald. The crew ran over a few hours, but were allowed to stay because of Dave Barry, then a columnist for the Herald, who wrote the book the movie is based upon.
Big Trouble marks Sofía Vergara's entry into American cinema and television.
Patrick Warburton, who plays Officer Walter Kramitz, played in Dave's World (1993), a sitcom based around writer/journalist Dave Barry, who wrote the book on which this movie was based. He was Dave's neighbor Eric.