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- Meet a child genius named Sheldon Cooper (already seen as an adult in The Big Bang Theory (2007)) and his family. Some unique challenges face Sheldon, who is socially impaired.
- A drama centered on the personal and professional lives of five surgical interns and their supervisors.
- He's smart. He's lovable. He's Dexter Morgan, America's favorite serial killer, who spends his days solving crimes and nights committing them.
- A chemistry teacher diagnosed with inoperable lung cancer turns to manufacturing and selling methamphetamine with a former student in order to secure his family's future.
- Follows the Major Case Response Team (MCRT) from the Naval Criminal Investigative Service (NCIS), as they get to the bottom of criminal cases connected to Navy and Marine Corps personnel.
- Two brothers follow their father's footsteps as hunters, fighting evil supernatural beings of many kinds, including monsters, demons, and gods that roam the earth.
- Using a crack team of doctors and his wits, an antisocial maverick doctor specializing in diagnostic medicine does whatever it takes to solve puzzling cases that come his way.
- New Jersey mob boss Tony Soprano deals with personal and professional issues in his home and business life that affect his mental state, leading him to seek professional psychiatric counseling.
- Shaun Murphy, a young surgeon with autism and Savant syndrome, is recruited into the surgical unit of a prestigious hospital.
- A scrappy, feisty, fiercely loyal Chicago family makes no apologies.
- The series follows Adrian Monk, a brilliant former San Francisco detective, who now consults the police as a private consultant whilst battling with an obsessive-compulsive disorder.
- Claire Beauchamp Randall, a nurse in World War II, mysteriously goes back in time to Scotland in 1743. There, she meets a dashing Highland warrior and gets drawn into an epic rebellion.
- Follows the personal and professional lives of six twenty to thirty year-old friends living in the Manhattan borough of New York City.
- Various chronicles of deception, intrigue, and murder in and around frozen Minnesota. All of these tales mysteriously lead back one way or another to Fargo, North Dakota.
- Three different, but related, families face trials and tribulations in their own uniquely comedic ways.
- Comedy series following the exploits of Det. Jake Peralta and his diverse, lovable colleagues as they police the NYPD's 99th Precinct.
- The continuing misadventures of neurotic New York City stand-up comedian Jerry Seinfeld and his equally neurotic New York City friends.
- Two F.B.I. Agents, Fox Mulder the believer and Dana Scully the skeptic, investigate the strange and unexplained, while hidden forces work to impede their efforts.
- The quirky spin on Conan Doyle's iconic sleuth pitches him as a "high-functioning sociopath" in modern-day London. Assisting him in his investigations: Afghanistan War vet John Watson, who's introduced to Holmes by a mutual acquaintance.
- A famous "psychic" outs himself as a fake, and starts working as a consultant for the California Bureau of Investigation so he can find "Red John", the madman who killed his wife and daughter.
- A new FBI profiler, Elizabeth Keen, has her entire life uprooted when a mysterious criminal, Raymond Reddington, who has eluded capture for decades, turns himself in and insists on speaking only to her.
- A hedonistic jingle writer's free-wheeling life comes to an abrupt halt when his brother and 10-year-old nephew move into his beach-front house.
- Three parapsychologists forced out of their university funding set up shop as a unique ghost removal service in New York City, attracting frightened yet skeptical customers.
- Set almost 100 years after Captain Kirk's 5-year mission, a new generation of Starfleet officers sets off in the U.S.S. Enterprise-D on its own mission to go where no one has gone before.
- The doctors who work in the ER at the County General Hospital in Chicago grapple with ups and downs in their personal and professional lives while trying to give apt medical care to their patients.
- A young Clark Kent struggles to find his place in the world as he learns to harness his alien powers for good and deals with the typical troubles of teenage life in Smallville, Kansas.
- Professional writer and amateur sleuth Jessica Fletcher uses her intellect, charm, and persistence to get to the bottom of every crime she encounters.
- Based on the true story of Jordan Belfort, from his rise to a wealthy stock-broker living the high life to his fall involving crime, corruption and the federal government.
- A chronicle of the lives of a dysfunctional family who run an independent funeral home in Los Angeles.
- When a beautiful stranger leads computer hacker Neo to a forbidding underworld, he discovers the shocking truth--the life he knows is the elaborate deception of an evil cyber-intelligence.
- Secrets and truths unfold through the lives of female friends in one suburban neighborhood after the mysterious suicide of a neighbor.
- Los Angeles homicide detective Lieutenant Columbo uses his humble ways and ingenuous demeanor to winkle out even the most well-concealed of crimes.
- In the unreal world of Sacred Heart Hospital, intern John "J.D." Dorian learns the ways of medicine, friendship and life.
- A gifted young teen tries to survive life with his dimwitted, dysfunctional family.
- Three Halliwell sisters discover that they are descendants of a line of good female witches and are destined to fight against the forces of evil, using their combined power of witchcraft known as the "Power of Three".
- The misadventures of a talking sea sponge who works at a fast food restaurant, attends a boating school, and lives in an underwater pineapple.
- Living a life marked by violence, neo-Nazi Derek finally goes to prison after killing two black youths. Upon his release, Derek vows to change; he hopes to prevent his brother, Danny, who idolizes Derek, from following in his footsteps.
- A cyborg, identical to the one who failed to kill Sarah Connor, must now protect her ten year old son John from an even more advanced and powerful cyborg.
- After being bitten by a genetically-modified spider, a shy teenager gains spider-like abilities that he uses to fight injustice as a masked superhero and face a vengeful enemy.
- In the ancient battle of Thermopylae, King Leonidas and 300 Spartans fight against Xerxes and his massive Persian army. They face insurmountable odds when they are betrayed by a Spartan reject.
- Epic series reveals the scandalous life of a young king whose affairs and obsession with producing a male heir changed marriage, the church, and the world.
- NCIS's covert operations team go undercover to investigate cases involving terrorism and National Security.
- The Philadelphia homicide squad's lone female detective finds her calling when she's assigned "cold cases," older crimes that have never been solved.
- Goaded by his buddies, a nerdy guy who's never "done the deed" only finds the pressure mounting when he meets a single mother.
- After uncovering a mysterious artifact buried beneath the Lunar surface, a spacecraft is sent to Jupiter to find its origins: a spacecraft manned by two men and the supercomputer HAL 9000.
- Deliveryman Doug Heffernan has a good life: He has a pretty wife (Carrie), a big television, and friends with which to watch it. Then Carrie's goofy, annoying father Arthur moves in with them.
- A new medical director breaks the rules to heal the system at America's oldest public hospital.
- Two disgraced FBI agents go way undercover in an effort to protect hotel heiresses the Wilson sisters from a kidnapping plot.
- Following a ghost invasion of Manhattan, paranormal enthusiasts Erin Gilbert and Abby Yates, nuclear engineer Jillian Holtzmann, and subway worker Patty Tolan band together to stop the otherworldly threat.
- When a suburban mother turns to dealing marijuana in order to maintain her privileged lifestyle after her husband dies, she finds out just how addicted her entire neighborhood already is.