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1-44 of 44
- A small town in Kansas is literally left in the dark after seeing a mushroom cloud over nearby Denver, Colorado. The townspeople struggle to find answers about the blast and solutions on how to survive.
- A small Kansas town struggles with life after a nuclear attack destroys America.
- Jake rallies Jericho residents to take shelter from fallout from the nuclear bomb that destroyed Denver. However, the shelter is uninhabitable.
- Satellite news reports the extent of the nuclear catastrophe to the shell-shocked townspeople, and Stanley claims he saw tanks rolling into Denver.
- When power is suddenly restored to the town, the results are mixed.
- When a barely conscious outsider is found looting the pharmacy for supplies, his identity and treatment cause controversy. Elsewhere, the desperate need for fuel endangers both parties and patients.
- Townspeople tap into their "bully" as they begin to realize rescue will not be soon, and interesting negotiations occur at the Richmond farm.
- Gray returns and his experiences have rattled him... to the detriment of the town, Jake negotiates with someone he hoped he wouldn't have to, and Johnston remains ill.
- Jake and Eric go on a desperate mission to get medicine for their father, but what they find at the hospital may prevent them from ever returning.
- Supplies dropped by airplanes throw the town into an uproar that Gray capitalizes on, and Jonah makes a move that will have far-reaching effects.
- The mercenaries follow Jake and Eric home and the resulting crisis makes the town face how defenseless they are.
- Set 36 hours before the bombs' detonation, Jake and Hawkins lives are shown and how they ended up in Jericho.
- Gray makes his move, aided by hysteria that ensues after a murder, Bonnie may take up with the wrong person out of hurt feelings, and Jonah complicates everyones lives... again.
- A trip to a trading outpost for a windmill part turns risky when a rule is broken. Back at home, Roger finally reveals to Emily a little of what happened to him, and Gail gets some things off her chest to Mary.
- Jake, Stanley and Mimi run into difficulties on a hunting trip.
- April faces a complicated pregnancy, while Hawkins tries to cover up Sarah Mason's death.
- The marines come to town, offering Anderson an easy way out of hard decisions, but their behavior raises Jake's and Johnston's suspicions.
- Roger takes extreme measures when Gray decides to kick the refugees out of town, and Hawkins begins the process of finding who's coming after him.
- Jake discovers Hawkins has not been completely honest about his background.
- When the windmills and townsmen are returned early and Eric is not with them, Jake and Hawkins go to New Bern to try and find him, but what they uncover has disturbing ramifications for Jericho.
- New Bern makes its move, and Gray falters.
- An incident at the salt mine escalates the tensions between Jericho and New Bern. Jake receives assistance from an unexpected acquaintance.
- The battle with New Bern ensues, with Jericho residents out-manned and out-gunned, but not outsmarted. A friend of Jake's sends help from an unexpected source.
- Three months after the battle with New Bern tensions are still high between the towns, and Jake has set his sights on Constantino despite warnings from the militia leader; meanwhile, Hawkins meets up with an unexpected ally.
- The self-appointed president from Wyoming visits town, providing Hawkins an opportunity to get information, but it puts both Darcy and Jake at risk.
- Dale returns from trading with news that the Hudson River Virus has crossed the Mississippi River, and when the town's vaccine supply is seized Jake coordinates a retrieval operation. Elsewhere, Hawkins is forced to show part of his hand to Beck.
- Dale's smuggling route is threatened, Hawkins creates an elaborate ruse to get Beck away from his office, and an apparent accounting error found by Mimi has devastating consequences.
- Jake blockades the hospital to prevent another tragedy, New Bern comes calling for Heather, and Goetz may finally get his just dues.
- Major Beck moves against the rangers in retaliation of Goetz's shooting, and Jake's surrender subjects him to extreme measures. Meanwhile, Hawkins decides to move the bomb, but a betrayal will put everything at risk.
- Jake and Hawkins risk their lives to retrieve the bomb and prevent Texas from joining with Wyoming; back at home, Beck is faced with some unpleasant truths, and Constantino offers a partnership.
- Andy, Lisa and the rest of the team work to save an 18-year-old college student in need of a double lung transplant, only to find that she cannot be placed on the list. Andy looks for alternatives to save her life. Meanwhile, Dr. Jordan has a patient in need of new kidneys and issues arise with the donor. Also, Andy and Miranda treat a former patient, who needs a new heart as well as a second chance with mending fences with his estranged son.
- At the Three Rivers Hospital in Pittsburgh, a clinic specializing in organ transplants, Dr. Andy Yablonski is the highly-skilled workaholic lead organ transplant surgeon, whose good-natured personality and sarcastic wit makes him popular with both his patients and colleagues. His co-workers include Dr. Miranda Foster, a surgical specialist with a rebellious streak and fiery temper who strives to live up to her deceased father's excellent surgical reputation; Dr. David Lee, a womanizing surgical resident who's broken as many hearts as he's replaced; Ryan Abbott, the inexperienced new transplant coordinator who arranges the intricately choreographed process of quickly and carefully transporting organs from donor to patient; Dr. Sophia Jordon, the dedicated head of surgery who has no patience for anyone who hasn't sacrificed as much as she has for the job; and Pam Acosta, Andy's no-nonsense operating assistant and best friend. In the season opener, a young pregnant woman's life hangs in the balance when she suffers a massive heart attack and Andy tells her that the only way to save her is for her to undergo a heart transplant. When complications arise with the donor's family, whom is a fatally injured construction foreman, Andy races the clock to save not only her life but that of her unborn child.
- Andy goes out on a limb for a patient, who is a former drug user in convincing the UNOS (United Network for Organ Sharing) to allow the transplant, which takes a turn for the worse when the patient disappears from the hospital before the surgery. Meanwhile, Dr. Jordan treats a very dedicated lawyer who ends up threatening to sue her. Also, David and Ryan encounter a unique situation when they head to pick the donation.
- Andy's police detective wife Rena, arrives at Three Rivers when her partner, Detective Phillip Lombardi, suffers a heart attack, where its soon revealed that Lombardi needs a new heart due to an aortic aneurysm. Andy ends up risking everything by trying a new procedure to save him. Meanwhile, an old patient returns to Three Rivers with a secret about Dr. Jordan.
- Following a bus crash, the parents of a high school football player must make a heartbreaking decision whether to donate his organs to save the lives of his fellow teammates. Meanwhile, Andy and Ryan race against the clock to find a procurement team to give a boy a heart transplant he desperately needs.
- Andy treats Victor, a car crash patient who's dying from ALS (amyotrophic lateral sclerosis) who wants to die from his injuries so his organs can be used to save others at Three Rivers. Meanwhile, David deals with the parent of three young foster children, suffering from pulmonary hypertension, who refuses to be admitted into the hospital. Miranda deals with a former heart recipient, named Barbara, who's new heart begins to cause complications, while Ryan is stuck with planning a donors-recipients reception at the hospital.
- Lisa responds to an accident at a local fair in which an eight-year-old boy is seriously injured and this bring up some painful memories. Meanwhile, Andy and David continue to work on getting a VAD for Kuol before it is too late. Also, Miranda and Dr. Jordan treat a young girl who collapsed during a gymnastic event and must deal with a personal issue.
- Tracy Allen is the wife of a San Francisco billionaire who arrives at Three Rivers in need of a new liver. But complications set in when David and Pam travel to Youngstown, Ohio to pick up one from the donor, a murder victim of highwaymen, a setback occurs when the liver is cancer ridden. As a result, Tracy's husband, John, defies Dr. Jordan's advice and resorts to buying a new liver for her on the black market. Meanwhile, a friend from Andy's criminal past, named Michael, resurfaces who anonymously gives a hearty donation to the hospital for Kuol's heart transplant as a bargaining chip to get Andy to resume his old life of crime before entering med school. Also, Miranda and Andy try to treat a young couple who are infected by an unknown pathogen.
- Andy must decide if he will allow a woman to start a "daisy chain" and donate her kidney to another patient on the chain until an exact match is found for her husband. Meanwhile, Andy suspects that a recent patient is rejecting his new heart.
- Dr. Jordon, Miranda, David, Andy and the others deal with the captain of a firehouse who needs a lung transplant. One of his firefighters must make the tough decision of whether or not she wants to be a living donor. Meanwhile, Andy faces a personal and professional dilemma when his uncle comes to Three Rivers for treatment from a stab wound, but requests that Andy keep it to himself.
- Andy's nemesis, arrogant heart surgeon Dr. Luc Bovell, returns to Three Rivers after a long absence and with pioneering robotics that could change the face of surgery at Three Rivers. Meanwhile, David's long-dormant Korean is tested when a Korean female air-passenger is admitted and he has to act as translator.
- Andy puts his patient Kuol at the top of the donor list to receive a new heart after his condition takes a turn for the worse. However, his transplant is put in jeopardy when the cops threaten to seize the money that was raised for Kuo's surgery.
- An unknown aggrieved man shoots new bride to be Kim Mullins. Her new husband Sam agrees to organ donation when she is declared brain dead but her mother Nancy is against it and gets a court order to stop Sam. Miranda goes out of her way to find lungs for her patient Mark Wilson and goes to South Carolina in the hope of harvesting Kim's organs and college basketball player Anton Weathers needs a new heart and hopes to benefit from Kim also but is devastated when he finds he will not be able to go pro after his transplant.
- Recap of the events of the past 11 episodes, from the day the bombs exploded to the events of "Vox Populi".