Sort by Popularity - Most Popular Movies and TV Shows tagged with keyword "rare-disease"
- Movies or TV
- Genres
- Keywords
- IMDb Rating
- Instant Watch Options
- In Theaters
- Release Year
1. Morbius (2022)
PG-13 | 104 min | Action, Adventure, Horror
Biochemist Michael Morbius tries to cure himself of a rare blood disease, but he inadvertently infects himself with a form of vampirism instead.
Director: Daniel Espinosa | Stars: Jared Leto, Matt Smith, Adria Arjona, Jared Harris
Votes: 153,417 | Gross: $73.87M
2. The Elephant Man (1980)
PG | 124 min | Biography, Drama
A Victorian surgeon rescues a heavily disfigured man who is mistreated while scraping a living as a side-show freak. Behind his monstrous façade, there is revealed a person of kindness, intelligence and sophistication.
Director: David Lynch | Stars: Anthony Hopkins, John Hurt, Anne Bancroft, John Gielgud
Votes: 258,456
3. Dirk Gently's Holistic Detective Agency (2016–2017)
TV-14 | 60 min | Action, Adventure, Comedy
Holistic detective Dirk Gently investigates cases involving the supernatural.
Stars: Samuel Barnett, Elijah Wood, Hannah Marks, Jade Eshete
Votes: 57,343
4. Midnight Sun (2018)
PG-13 | 91 min | Drama, Romance
A 17-year-old girl suffers from a condition that prevents her from being out in the sunlight.
Director: Scott Speer | Stars: Bella Thorne, Patrick Schwarzenegger, Rob Riggle, Quinn Shephard
Votes: 36,102 | Gross: $9.56M
5. One Fine Morning (2022)
R | 112 min | Drama, Romance
With a father suffering from neurodegenerative disease, a young woman lives with her eight-year-old daughter. While struggling to secure a decent nursing home, she runs into an unavailable friend with whom she embarks on an affair.
Director: Mia Hansen-Løve | Stars: Léa Seydoux, Pascal Greggory, Melvil Poupaud, Nicole Garcia
Votes: 6,897
6. Brain on Fire (2016)
PG-13 | 88 min | Biography, Drama
A young, capable professional cannot explain her newly erratic behavior.
Director: Gerard Barrett | Stars: Chloë Grace Moretz, Thomas Mann, Richard Armitage, Carrie-Anne Moss
Votes: 24,182
7. The Unbreakable Boy (2025)
PG | Drama | Completed
A young boy with both a rare brittle-bone disease and autism. But what makes him truly unique is his joyous, funny, life-affirming world view that transforms and unites everyone around him.
Director: Jon Gunn | Stars: Meghann Fahy, Zachary Levi, Amy Acker, Patricia Heaton
8. More Beautiful for Having Been Broken (2019)
Not Rated | 111 min | Drama
A female FBI agent befriends a woman and her adorable, young, special needs son who live in the countryside. The women's friendship soon turns into romance but family secrets complicate things.
Director: Nicole Conn | Stars: Zoe Ventoura, Kayla Radomski, Cale Ferrin, Bruce Davison
Votes: 1,366
9. Spider Baby or, the Maddest Story Ever Told (1967)
Not Rated | 81 min | Comedy, Horror
A caretaker devotes himself to three demented siblings after their father's death.
Director: Jack Hill | Stars: Lon Chaney Jr., Carol Ohmart, Quinn K. Redeker, Beverly Washburn
Votes: 7,811
10. Paa (2009)
133 min | Comedy, Drama
A father tries to help his son cope with a rare condition that causes the young boy to age beyond his years.
Director: R. Balki | Stars: Amitabh Bachchan, Abhishek Bachchan, Vidya Balan, Paresh Rawal
Votes: 12,604 | Gross: $0.20M
11. Awoken (2019)
88 min | Horror, Mystery, Thriller
When nothing can be done for a Fatal Familial Insomnia patient at the hospital, a med student has her brother moved to a secret facility in the basement for alternative treatment. Is it demonic possession?
Director: Daniel J. Phillips | Stars: Erik Thomson, Sara West, Benson Jack Anthony, Matt Crook
Votes: 10,115
12. The 8-Year Engagement (2017)
119 min | Drama, Romance
Hisashi and Mai are set to have their wedding ceremony in three months. Unfortunately, Mai falls ill and lapses into a coma.
Director: Takahisa Zeze | Stars: Takeru Satoh, Tao Tsuchiya, Tetta Sugimoto, Hiroko Yakushimaru
Votes: 1,103
13. Crystal Heart (1986)
R | 103 min | Drama, Music, Romance
A 22 year old man who has lived inside a crystal room because of a rare illness, meets an up and coming rock star, and the two fall in love.
Director: Gil Bettman | Stars: Lee Curreri, Tawny Kitaen, Lloyd Bochner, May Heatherly
Votes: 284
14. Something to Live for: The Alison Gertz Story (1992 TV Movie)
100 min | Drama
An AIDS-stricken woman becomes a leader in the struggle to educate people about the disease and its prevention.
Director: Tom McLoughlin | Stars: Molly Ringwald, Lee Grant, Perry King, Roxana Zal
Votes: 487
15. Midnight Son (2011)
Not Rated | 88 min | Horror
Forced by a disease to drink human blood, Jacob must control his violent tendencies as local law enforcement narrow their focus on him as a suspect in a series of grisly murders.
Director: Scott Leberecht | Stars: Zak Kilberg, Maya Parish, Jo D. Jonz, Larry Cedar
Votes: 1,913
16. Please Teacher! (2002)
TV-MA | 25 min | Animation, Comedy, Romance
An alien who becomes a teacher, and a student start a relationship and have to keep it all secret.
Stars: Sôichirô Hoshi, Kikuko Inoue, Ayako Kawasumi, Sayaka Ôhara
Votes: 1,251
17. Murder on the Blackboard (1934)
Passed | 71 min | Comedy, Drama, Mystery
A pretty young music teacher is bludgeoned to death in Hildegarde's school, where she's reunited with Oscar, but the autopsy report says she was dying from poison too.
Director: George Archainbaud | Stars: Edna May Oliver, James Gleason, Bruce Cabot, Gertrude Michael
Votes: 791
18. Life According to Sam (2013)
TV-G | 94 min | Documentary, Biography, Drama
A moving look at a couple's inspiring efforts to save their only son Sam from the rare and fatal premature-aging disease of progeria.
Directors: Sean Fine, Andrea Nix | Stars: Sam Berns, Leslie Gordon, Scott Berns, Francis Collins
Votes: 952
19. My Only Ü (2008)
TV-PG | 107 min | Comedy, Drama, Romance
When sassy, spunky Winona is diagnosed with lupus, Bong, a guy who secretly loves her, will do everything for her to live to the fullest before she expires.
Director: Cathy Garcia-Sampana | Stars: Toni Gonzaga, Vhong Navarro, Dennis Padilla, Benjie Paras
Votes: 165
20. Angeliena (2021)
95 min | Comedy, Drama
After a string of life-changing revelations, a beloved parking attendant pieces a new plan together and chases her dream of traveling the world.
Director: Uga Carlini | Stars: Euodia Samson, Tshamano Sebe, Thapelo Mokoena, June van Merch
Votes: 1,425
21. Veneno Cura (2008)
90 min | Crime, Drama, Romance
Director: Raquel Freire | Stars: Margarida Carvalho, Sofia Marques, Sandra Rosado, Miguel Moreira
Votes: 105
22. La sabbia negli occhi (2017)
98 min | Drama
The life of a woman, Beatrice, married to Sergio, who works as a teacher, as a volunteer in helping people and helping her students as psychologist and pedagogist. A woman who loves and ... See full summary »
Director: Alessandro Zizzo | Stars: Adelmo Togliani, Giulio Urbano, Valentina Corti, Giorgio Consoli
23. Klondike Fury (1942)
Approved | 68 min | Action, Adventure, Drama
A neurosurgeon is thrown out of the medical profession after he performs a daring but unsuccessful surgery. He flees to Alaska, where his plane crashes in the frozen wilderness.
Director: William K. Howard | Stars: Edmund Lowe, Lucile Fairbanks, William Henry, Ralph Morgan
Votes: 110
24. Invisible Interviews (2022– )
Documentary
Invisible Interviews features stories from four families affected by the ultra-rare and largely unknown condition, Niemann-Pick disease, which is fatal and currently has no cure.
Stars: Sheila Reid, Graham Kirk, Nadia Slatch, Alec Koujaian
25. The Shell Collector (2016)
87 min | Drama
A blind conchologist who lives ion the island of Okinawa, Japan cures a rare disease afflicting Izumi who has washed up on the shore. having cured a rare disease through coincidence he is ... See full summary »
Director: Yoshifumi Tsubota | Stars: Masahiro Arakaki, Lily Franky, Akira Fukuhara, Ai Hashimoto
Votes: 52
26. Waterless (2015)
45 min | Drama
A young man becomes afflicted with a disease so rare that there is no record of it anywhere in world history. He is allergic to water. When a special secret research division of the U.S. ... See full summary »
Director: Marc I. Daniels | Stars: Drew Bolander, Terrence Montgomery, Kerri Dillon, Courtney Case
Votes: 22
27. A Rare Find (2023)
Short, Comedy
Through the late nights, early mornings and constant stream of nappy changes...a struggling young family discover a simple blood spot "heel prick" test may provide answers as to what is happening with their baby.
Director: John Lee Taggart | Stars: Robert Webb, Jack Robertson, Chantelle Taggart, Cora Lily Taggart
28. Our Curse (2013)
28 min | Documentary, Short, Drama
The film is a personal statement of the director and his wife, who have to deal with an incurable disease of their newborn son.
Director: Tomasz Sliwinski | Stars: Magda Hueckel, Tomasz Sliwinski, Leo Hueckel-Sliwinski
Votes: 400
29. Driven to Help (2022 TV Movie)
46 min | Documentary
Imagine a disease so rare there's no cure. Austin Crawford was diagnosed with MSA or Multiple System Atrophy. As his health fades we find Austin building a hot rod from his wheelchair and sharing his story to his followers on Tiktok.
Director: Phil Gioja | Star: Austin Crawford
Votes: 9
30. Go Make Memories (2019)
Animation, Short, Drama
"Go Make Memories", is a short film which hopes to raise awareness of the ultra-rare and devastating group of genetic conditions, Niemann-Pick disease (NPD). By using a mixture of live ... See full summary »
Director: Carl Mason | Stars: Lleyton Coombes, Emily Stride, Chris Hughes, Bodhi Rae Breathnach
31. Invisible Manners (2021)
6 min | Animation, Short
Invisible Manners is a short film on "invisible conditions" featuring the voices of Billy Boyd (The Lord of the Rings), Isy Suttie (Peep Show), Weruche Opia (I May Destroy You), and members and friends of the NPUK/INPDA community.
Director: John Lee Taggart | Stars: Billy Boyd, Isy Suttie, Weruche Opia, Aadam Asif
32. A Rare Life
Comedy, Drama | Announced
A bereaved husband struggles to navigate the darkness of his new world, favouring staying in bed all day than doing just about anything else. Well he's not getting off that easily, unfortunately for him.
Director: John Lee Taggart
33. Une personne rare (2016)
13 min | Documentary
Pierre lives in Paris and has FSHD Muscular Dystrophy. Emilie lives in Barcelona and has Dystonia. Charlie lives in Saint-Quentin and has Glass Bone Disease. Jean-Luc lives in Oostende and has Alkaptonuria.
34. Kathputli: A Struggle for Control (2017)
12 min | Short, Drama, Mystery
Story of a girl suffering from Alien Hand Syndrome, a rare neurological disease and about the stigma of mental illness in India.
Director: Mohit Trendster | Stars: Meena Yashpal, Ankita Tripathi, Richa Srivastava, Ani Yashpal
Votes: 9
35. Fighting MSA: Austin Crawford's Story (2020)
14 min | Documentary, Short
Facing a devastating disease with no known cause or cure, Austin Crawford claims to be 'the richest man in the world' as he fights to pay it forward and keep his head in the wind.
Director: Phil Gioja | Star: Austin Crawford
Votes: 11
36. In Crystal Skin (2015)
49 min | Documentary | Completed
Spread across Bogotá, Colombia, four individuals manage life with a rare skin disease.
Director: Michaela O'Brien
38. Shafon: An MPS VI Story (2009)
Not Rated | 55 min | Documentary
MPS VI is a rare genetic disease affecting 1 in 300,000 live births in America. Shafon Faith Seeden is one of them.
Director: Joe May
39. Project Purple: Mission Sarcoidosis Awareness (2023)
Documentary
Project Purple's mission is to ensure that the world knows the word Sarcoidosis, increase funding to Sarcoidosis Research, and make a positive impact on the quality of life for those living with chronic illness.
Director: Andrena Senola | Stars: Karen Duffy, Rhonda McCullough, Michael Mathis, Frank Rivera
40. Ces enfants rares (2003 TV Movie)
54 min | Documentary
A documentary film about rare genetic disorder Prader-Willi Syndrome and inherited metabolic diseases (inborn errors of metabolism).
Director: Isabelle Saunois
41.
House M.D. (2004–2012)
Episode:
Paternity
(2004)
TV-14 | 43 min | Drama, Mystery
The team helps a high school boy (16) who has double vision and night terrors. (Clinic Cases: Unvaccinated baby, man with boil on leg.)
Director: Peter O'Fallon | Stars: Hugh Laurie, Lisa Edelstein, Omar Epps, Robert Sean Leonard
Votes: 4,559
42.
Sky King (1951–1962)
Episode:
Cindy, Come Home
(1958)
TV-PG | Adventure, Drama, Family
A doctor informs Sky that the only thing that will help a sick girl is finding her missing father. Sky goes on the hunt for missing man.
Director: Clark L. Paylow | Stars: Kirby Grant, Gloria Winters, William Hudson, Darcy Hinton
Votes: 8
43.
Star Trek (1966–1969)
Episode:
The Mark of Gideon
(1969)
TV-PG | 51 min | Action, Adventure, Sci-Fi
Kirk beams down to the planet Gideon and appears to find himself trapped on a deserted Enterprise. Spock on the real Enterprise must use his diplomatic skills to deal with the uncooperative inhabitants of Gideon and find the Captain.
Director: Jud Taylor | Stars: William Shatner, Leonard Nimoy, DeForest Kelley, Sharon Acker
Votes: 3,013
44.
Star Trek: The Next Generation (1987–1994)
Episode:
Bloodlines
(1994)
TV-PG | 46 min | Action, Adventure, Drama
Picard races the Ferengi in an effort to track down the son he never knew he had.
Director: Les Landau | Stars: Patrick Stewart, Jonathan Frakes, LeVar Burton, Michael Dorn
Votes: 2,524
45.
Superman: The Animated Series (1996–2000)
Episode:
The Way of All Flesh
(1996)
Unrated | 22 min | Animation, Action, Adventure
John Corben returns as a kryptonite-powered cyborg eager to kill Superman.
Director: Kenji Hachizaki | Stars: Tim Daly, Dana Delany, Clancy Brown, Malcolm McDowell
Votes: 559
46.
The X-Files (1993–2018)
Episode:
Our Town
(1995)
TV-14 | 44 min | Crime, Drama, Mystery
Reports of foxfire on a field in Dudley, Arkansas lead Mulder and Scully to a bizarre situation regarding the townsfolk. Employees of the Chaco Chicken Corporation are displaying bizarre behavior, and the death rate is slowly increasing.
Director: Rob Bowman | Stars: David Duchovny, Gillian Anderson, Caroline Kava, John Milford
Votes: 4,581
47.
House M.D. (2004–2012)
Episode:
All In
(2006)
TV-14 | 44 min | Drama, Mystery
On a class field trip, a teacher discovers that her six-year-old student, Ian, is bleeding profusely. Dr. House thinks Ian has the same unknown disease that killed an elderly patient of his years ago.
Director: Fred Gerber | Stars: Hugh Laurie, Lisa Edelstein, Omar Epps, Robert Sean Leonard
Votes: 3,796
48.
House M.D. (2004–2012)
Episode:
Insensitive
(2007)
TV-14 | 44 min | Drama, Mystery
On Valentine's Day, House meddles in relationships as he works to diagnose a teenager who has a genetic inability to feel pain.
Director: Deran Sarafian | Stars: Hugh Laurie, Lisa Edelstein, Omar Epps, Robert Sean Leonard
Votes: 3,159
49.
Surgeons: At the Edge of Life (2018–2024)
Episode:
Pushing The Boundaries
(2019)
59 min | Documentary
Tim Martin operates on a woman with a disease so rare, he is thought to be the first in the UK to attempt the procedure. Neurosurgeon Alex Paluzzi is taking on one of the toughest cases of his career too.
Directors: Jonny Ashton, Stuart Bernard, Damian O'Mahony | Star: Shaun Dooley
50.
Forensic Files (1996–2011)
Episode:
With Every Breath
(1999)
TV-14 | 21 min | Documentary, Crime
Young Navajos on a reservation in the southwest were dying at an alarming rate. CDC officials had never seen anything like it; the mysterious illness had claimed the lives of more than 20 ... See full summary »
Stars: Peter Thomas, Bita Begay, Patricia McFeely, Ben Muneta
Votes: 97