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- CreatorJoss WhedonStarsNathan FillionGina TorresAlan TudykFive hundred years in the future, a renegade crew aboard a small spacecraft tries to survive as they travel the unknown parts of the galaxy and evade warring factions as well as authority agents out to get them.
- CreatorGene RoddenberryStarsPatrick StewartBrent SpinerJonathan FrakesSet almost 100 years after Captain Kirk's 5-year mission, a new generation of Starfleet officers sets off in the U.S.S. Enterprise-D on its own mission to go where no one has gone before.
- CreatorRick BermanMichael PillerStarsAvery BrooksRene AuberjonoisCirroc LoftonIn the vicinity of the liberated planet of Bajor, the Federation space station Deep Space Nine guards the opening of a stable wormhole to the far side of the galaxy.
- CreatorRick BermanMichael PillerJeri TaylorStarsKate MulgrewRobert BeltranRoxann DawsonPulled to the far side of the galaxy, where the Federation is seventy-five years away at maximum warp speed, a Starfleet ship must cooperate with Maquis rebels to find a way home.
- CreatorRick BermanBrannon BragaStarsScott BakulaJohn BillingsleyJolene BlalockA century before Captain Kirk's five-year mission, Jonathan Archer captains the United Earth ship Enterprise during the early years of Starfleet, leading up to the Earth-Romulan War and the formation of the Federation.
- CreatorBill LawrenceStarsZach BraffDonald FaisonSarah ChalkeIn the unreal world of Sacred Heart Hospital, intern John "J.D." Dorian learns the ways of medicine, friendship and life.
- CreatorGregory Thomas GarciaStarsJason LeeEthan SupleeJaime PresslyA ne'er do well wins $100,000 in the lottery and decides to right all the wrongs from his past with his newfound realization!
- CreatorDarren StarStarsSarah Jessica ParkerKim CattrallKristin DavisFour female New Yorkers gossip about their sex lives (or lack thereof) and find new ways to deal with being a woman in the late 1990s.
- CreatorGary David GoldbergBill LawrenceStarsMichael J. FoxCharlie SheenHeather LocklearMike Flaherty, the Deputy Mayor of New York City, and his team of half-wits must constantly save the Mayor from embarrassment and the media. Mike is later succeeded by Charlie Crawford.
- CreatorGary David GoldbergStarsMichael J. FoxMichael GrossMeredith BaxterChronicles liberal ex-hippies Steven and Elyse Keaton, their conservative son Alex, daughters Mallory and Jennifer, and later, youngest child Andrew.
- CreatorDavid E. KelleyStarsJames SpaderWilliam ShatnerCandice BergenBoston Legal is a spin-off of the long-running David E. Kelley series The Practice (1997), following the exploits of former Practice character Alan Shore (James Spader) at the legal firm of Crane, Poole, and Schmidt.
- CreatorDavid CraneMarta KauffmanStarsJennifer AnistonCourteney CoxLisa KudrowFollows the personal and professional lives of six twenty to thirty year-old friends living in the Manhattan borough of New York City.
- CreatorMark FrostDavid LynchStarsKyle MacLachlanMichael OntkeanMädchen AmickAn idiosyncratic FBI agent investigates the murder of a young woman in the even more idiosyncratic town of Twin Peaks.
- CreatorWill ArnettMitchell HurwitzJames VallelyStarsWill ArnettKeri RussellStefania LaVie OwenSteven Wilde always had everything he wanted, due to his improbably rich father. Except the girl, Emmy Kadubic, who is an environmentalist. Emmy and her daughter, Puddle come to live with him.
- CreatorShana Goldberg-MeehanScott SilveriStarsMatt LeBlancPaulo CostanzoDrea de MatteoIn this spin-off of Friends (1994), Joey Tribbiani moves to Los Angeles to pursue his acting career.
- CreatorAllison M. GibsonStarsReba McEntireJoAnna Garcia SwisherSteve HoweyReba McEntire stars as the titular character in this smash sitcom about a single mom of three, navigating life in a Houston suburb.
- CreatorDavid KohanMax MutchnickStarsEric McCormackDebra MessingMegan MullallyGay lawyer Will and straight interior designer Grace share a New York City apartment. Their best friends are gleeful and proud gay Jack and charismatic, filthy-rich, amoral socialite Karen.
- CreatorTracy GambleStarsKatey SagalKaley CuocoAmy DavidsonThe Hennessy clan -- mother Cate, daughters Bridget and Kerry, and son Rory -- look to one another for guidance and support after the death of Paul, the family patriarch. Cate's parents lend a hand.
- CreatorConstance M. BurgeStarsHolly Marie CombsAlyssa MilanoBrian KrauseThree Halliwell sisters discover that they are descendants of a line of good female witches and are destined to fight against the forces of evil, using their combined power of witchcraft known as the "Power of Three".
- CreatorMichelle NaderStarsMolly ShannonSelma BlairJohn Michael HigginsU.S. version of the hit Australian comedy about a dysfunctional mother and daughter relationship.
- CreatorEthan ReiffCyrus VorisStarsMichael EalyOded FehrHenri LubattiAn American undercover FBI agent is assigned to infiltrate a terrorist sleeper cell that is planning an attack in Los Angeles.
- CreatorTom FontanaStarsErnie HudsonJ.K. SimmonsLee TergesenA series chronicling the daily activities of an unusual prison facility and its criminal inhabitants.
- CreatorAnthony YerkovichStarsDon JohnsonPhilip Michael ThomasSaundra Santiago-Resplendent with authentic 1980s music, fashion, and vibe, "Miami Vice" follows two undercover detectives and their extended team through the mean streets of Miami, Florida.
- CreatorMichael PillerShawn PillerStarsAnthony Michael HallNicole de BoerChris BrunoJohnny had the perfect life until he was in coma for six years. When he awoke, he found his fiancee married to another man. His son doesn't know him. Everything's changed, including Johnny. With one touch, he can see things.
- CreatorRené EchevarriaScott PetersStarsJacqueline McKenzieJoel GretschPatrick John FluegerAs the reappearance of 4,400 missing persons on a single day confounds the global community, federal agents on the case slowly discover the ways in which the victims have been changed.