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- CreatorJames L. BrooksMatt GroeningSam SimonStarsDan CastellanetaNancy CartwrightHarry ShearerThe satiric half-hour adventures of a working-class family in the misfit city of Springfield.
- CreatorJ.G. QuintelStarsJ.G. QuintelWilliam SalyersSam MarinThe surreal misadventures of two best friends - a blue jay and a raccoon - as they seek to liven up their mundane jobs as groundskeepers at the local park.
- CreatorTrey ParkerMatt StoneBrian GradenStarsTrey ParkerMatt StoneIsaac HayesFollows the misadventures of four irreverent grade-schoolers in the quiet, dysfunctional town of South Park, Colorado.
- CreatorRaphael Bob-WaksbergStarsWill ArnettAmy SedarisAlison BrieBoJack Horseman was the star of the hit television show "Horsin' Around" in the '80s and '90s, but now he's washed up, living in Hollywood, complaining about everything, and wearing colorful sweaters.
- CreatorDan HarmonJustin RoilandStarsChris ParnellSpencer GrammerSarah ChalkeThe fractured domestic lives of a nihilistic mad scientist and his anxious grandson are further complicated by their inter-dimensional misadventures.
- CreatorTom RueggerStarsRob PaulsenJess HarnellTress MacNeilleThe zany adventures of a trio of 1930s animated characters in the modern world.
- CreatorRebecca SugarStarsZach CallisonDeedee MagnoMichaela DietzA team of intergalactic warriors fights to protect the Earth, but the combination of three highly trained beings and one quirky young boy leaves the team struggling to overcome the dangerous scenarios that are put in front of them.
- CreatorJohn DilworthStarsMarty GrabsteinThea WhitePeter FernandezThe offbeat adventures of Courage, a cowardly dog who must overcome his own fears to heroically defend his unknowing farmer owners from all kinds of dangers, paranormal events and menaces that appear around their land.
- CreatorAlex HirschStarsJason RitterAlex HirschKristen SchaalTwin siblings Dipper and Mabel Pines spend the summer at their great-uncle's tourist trap in the enigmatic Gravity Falls, Oregon.
- CreatorGlenn EichlerSusie LewisStarsTracy GrandstaffWendy HoopesJulian RebolledoA smart and cynical girl goes through teenage life as a proud outsider in a world of mainly idiotic adolescents and condescending adults.
- CreatorDavid X. CohenMatt GroeningStarsBilly WestJohn DiMaggioKatey SagalPhilip J. Fry, a pizza delivery boy, is accidentally frozen in 1999 and thawed out on New Year's Eve 2999.
- CreatorPendleton WardStarsJohn DiMaggioJeremy ShadaTom KennyA 12-year-old boy and his best friend, a wise 28-year-old dog with magical powers, go on a series of surreal adventures in a remote future.
- StarsMaurice LaMarcheRob PaulsenTress MacNeillePinky and Brain are genetically enhanced laboratory mice who reside in the research facility. Brain is self-centered and scheming; Pinky is good-natured but feeble-minded. In each episode, Brain devises a new plan to take over the world.
- CreatorMike LazzoKhaki JonesStarsGeorge LoweC. Martin CrokerAndy MerrillSpace Ghost, a superhero from a 1960s Hanna-Barbera cartoon, hosts his own talk show.
- CreatorSavage Steve HollandBill KoppStarsBill KoppSavage Steve HollandCharlie AdlerThe comical misadventures of Eek, a kind-hearted anthropomorphic purple cat who finds himself in constant mortal danger while trying to help others. The show had two more segments - The Terrible Thunderlizards and Klutter.
- CreatorJeff AstrofGabor CsupoArlene KlaskyStarsLacey ChabertJodi CarlisleTim CurryEliza Thornberry is not your ordinary kid. It's not just because she travels the world in an RV with her parents: famous nature show hosts. Eliza also happened to be granted the magical ability to talk with and understand animals.
- CreatorRichard ZielenkiewiczStarsArthur HoldenSonja BallRick JonesRapido and Razmo, two humor-infested rodents, have found their paradise! They are squatting an old Cargo ship: on board are 5,000 tons of cheese.
- CreatorDoug LangdaleStarsDanny CookseyJeff BennettEstelle HarrisFollow the adventures of Dave, one incredibly unusual barbarian, who's more interested in raising his family and cooking yummy gourmet meals than conquering new lands.
- CreatorDavid FineAlison SnowdenStarsAlison SnowdenJamie WatsonAndy HamiltonBased on the animated short Bob's Birthday (1993), this series follows the daily adventures of a London dentist and his chiropodist wife.
- CreatorBill OakleyJosh WeinsteinStarsBrian PosehnNick JamesonWallace LanghamThe misadventures of a group of disparate roommates who live in a hip neighborhood in a major city.
- CreatorJoe MurrayStarsCarlos AlazraquiTom KennyCharlie AdlerThe wacky misadventures of an Australian wallaby and his friends as he finishes his transition to American life.
- CreatorMaxwell AtomsStarsGreg EaglesRichard Steven HorvitzGrey GriffinThe ill-tempered Grim Reaper gets into a wager that forces him to become the life-long companions of two scheming youngsters after he loses.
- CreatorGeorge KrsticJody SchaefferStarsDavid DeLuiseWendee LeeSteve BlumTwo teenage slackers find a mecha from the future that had been lying in a New Jersey junkyard for nearly 60 years and make modifications much to the dismay of the robot's attractive creator.
- CreatorCraig McCrackenStarsCathy CavadiniElizabeth DailyTara StrongThree super-powered little girls constantly save the world (or at least the city of Townsville) from monsters, would-be conquerers and a few other gross things.
- CreatorVan PartibleStarsJeff BennettBrenda VaccaroMae WhitmanThe misadventures of a dumb blond egomaniac who severely overestimates his own manliness and his supposed "success" with women.