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- DirectorDavid StraitonStarsHugh LaurieLisa EdelsteinOmar EppsWhen a researcher at a South Pole base becomes ill, House must diagnose the case at a distance. Meanwhile, House tries to find out who Wilson is dating, and his new staff tries to get him cable.
- DirectorGreg YaitanesStarsHugh LaurieLisa EdelsteinOmar EppsA bus that House was riding crashes. House claims there's a victim on the bus who is dying, but not from the bus accident. He stops at nothing to figure out who the patient is and what is ailing him/her.
- DirectorParis BarclayStarsHugh LaurieLisa EdelsteinOmar EppsHouse's ex Stacy Warner asks him to treat her husband. House takes over a diagnostics class for a day and presents the class with three case studies of leg pain. As House tells his story and the class gradually fills up with listeners, the class learns a lot about how to be better doctors, and Chase, Foreman and Cameron learn some important details of House's past.
- DirectorDaniel AttiasStarsHugh LaurieLisa EdelsteinOmar EppsHouse treats a patient on death row while Dr. Cameron avoids telling a patient she has a terminal illness.
- DirectorJace AlexanderStarsHugh LaurieLisa EdelsteinOmar EppsWhen a famous writer is brought in with language difficulties, House must assist via phone while waiting for a delayed plane.
- DirectorFred GerberStarsHugh LaurieLisa EdelsteinOmar EppsOn a class field trip, a teacher discovers that her six-year-old student, Ian, is bleeding profusely. Dr. House thinks Ian has the same unknown disease that killed an elderly patient of his years ago.
- DirectorDeran SarafianStarsHugh LaurieLisa EdelsteinOmar EppsHouse tries radical procedures to save Foreman's life; Foreman's father visits.
- DirectorDavid ShoreStarsHugh LaurieLisa EdelsteinOmar EppsAn old patient of House comes back and seeks revenge upon him in the form of gunshot.
- DirectorNewton Thomas SigelStarsHugh LaurieLisa EdelsteinOmar EppsA ten-year-old boy begins screaming in pain, but nobody knows why, because he is autistic and cannot explain. House refuses to use his office because it has new carpet.
- DirectorTony ToStarsHugh LaurieLisa EdelsteinOmar EppsWilson presents the deal to House and then convinces Cuddy to back him up, meanwhile the team is flummoxed by a patient's condition and various members keep seeking out House for his opinion even though he may not be prepared to assist.
- DirectorJuan José CampanellaStarsHugh LaurieLisa EdelsteinOmar EppsStuck with clinic duty, House almost wishes he had the boring patients back after he encounters a young woman with an STD and the need to talk.
- DirectorMatt ShakmanStarsHugh LaurieLisa EdelsteinOmar EppsWhen a pregnant woman has a stroke, the team is at a loss after all tests reveal nothing, but when her organs start shutting down Cuddy takes over the case.
- DirectorKatie JacobsStarsHugh LaurieLisa EdelsteinOmar EppsThe team works to save someone close to a central character's heart. The key is inside House's head, but he is in a bad way himself.
- DirectorGreg YaitanesStarsHugh LaurieLisa EdelsteinOmar EppsHouse and his team treat a patient who had his brain split in half, now it seems like one side of his brain is causing some health/behavioral issues. House plays games with Cuddy over the night he detoxed, and those events will cause major changes. Cameron and Chase come to a decision.
- DirectorDaniel AttiasStarsHugh LaurieLisa EdelsteinOmar EppsHouse is injured in a motorcycle accident. While recovering, he finds an accident victim suffering from a brain injury. House tries to prove the brain damage caused the accident, not vice versa, so he can treat the patient.
- DirectorKatie JacobsStarsHugh LaurieLisa EdelsteinOmar EppsA person takes House, Thirteen and others as hostages. He's seen several doctors but none have found what ails him. As they work towards finding a solution, Thirteen makes decisions which leads her to think about her own condition.
- DirectorDavid StraitonStarsHugh LaurieLisa EdelsteinOmar EppsWhen all of House's efforts to rid himself of Amber fail, he turns to someone unexpected for assistance. Meanwhile, the team is left to fend for itself as they try to save a ballerina's life and career.
- DirectorGreg YaitanesStarsHugh LaurieLisa EdelsteinOmar EppsHouse's Amber hallucination becomes more aggressive as sleep deprivation takes its toll endangering a patient, and Chase's bachelor party ends in the emergency room.
- DirectorKatie JacobsStarsHugh LaurieRobert Sean LeonardFranka PotenteHouse fights his doctors, the staff and his fellow patients when he's forced to stay in the psychiatric hospital under threat of permanently losing his medical license.
- DirectorLesli Linka GlatterStarsHugh LaurieLisa EdelsteinOmar EppsWhen an old friend and former patient of Wilson's experiences paralysis in his right arm, Wilson puts himself on the case. House wagers Wilson that the patient's symptoms result from new cancer cells. Wilson accepts even though he is reluctant to believe the cancer has returned. With the help of the team, Wilson works to find a more optimistic diagnosis, but when things take a turn for the worse, and Wilson must address his inability to separate patient from friend. Meanwhile, Cuddy seeks advice in her search for real estate.
- DirectorHugh LaurieStarsHugh LaurieLisa EdelsteinOmar EppsWhen a newborn disappears from the nursery, Princeton Plainsboro goes on lockdown, preventing anyone from entering, leaving or moving within the hospital. While House and his team members are trapped in various parts of the building, new insights about the team's personal histories, relationships and regrets surface.
- DirectorDavid StraitonStarsHugh LaurieLisa EdelsteinOmar EppsAt therapy with Dr. Nolan, House tells about a cute amnesiac in ER, Wilson throwing him out and his old apartment being a mess after Alvarez broke in.
- DirectorGreg YaitanesStarsHugh LaurieLisa EdelsteinOmar EppsCuddy, House and members of the team join forces with a search-and-rescue team to provide much-needed medical attention at the scene of an emergency.