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- CreatorDavid X. CohenMatt GroeningStarsBilly WestJohn DiMaggioKatey SagalPhilip J. Fry, a pizza delivery boy, is accidentally frozen in 1999 and thawed out on New Year's Eve 2999.
- CreatorMike JudgeStarsMike JudgeKristofor BrownDale RevoAnimated MTV series about two teenage heavy-metal music fans who occasionally do idiotic things because they're bored. For them, everything is "cool" or "sucks."
- CreatorTim MillerStarsFred TatascioreScott WhyteNolan NorthA collection of animated short stories that span various genres including science fiction, fantasy, horror and comedy.
- CreatorRaphael Bob-WaksbergStarsWill ArnettAmy SedarisAlison BrieBoJack Horseman was the star of the hit television show "Horsin' Around" in the '80s and '90s, but now he's washed up, living in Hollywood, complaining about everything, and wearing colorful sweaters.
- CreatorDino StamatopoulosStarsCarolyn LawrenceScott AdsitBritta PhillipsA parody of past religious-geared animated shows starring Orel, an optimistic God-fearing young boy in a world of cynicism.
- CreatorDavid FeissStarsCharlie AdlerCandi MiloDee Bradley BakerThe program focuses on the misadventures of two unlikely yet somehow biological siblings: Cow and Chicken.
- CreatorAdam ReedStarsH. Jon BenjaminJudy GreerAmber NashCovert black ops and espionage take a back seat to zany personalities and relationships between secret agents and drones.
- CreatorGenndy TartakovskyStarsAaron LaPlanteLaëtitia EïdoFred TatascioreA caveman and a dinosaur bond over shared tragedy and work together to survive in a perilous prehistoric world.
- CreatorDave WillisJim FortierMatt MaiellaroStarsBobby EllerbeeDana SnyderDaniel McDevittFollows the adventures of the Cuylers, an impoverished and dysfunctional family of anthropomorphic, air-breathing, redneck squids who live in a rural Appalachian community in the state of Georgia.
- CreatorTrey ParkerMatt StoneBrian GradenStarsTrey ParkerMatt StoneIsaac HayesFollows the misadventures of four irreverent grade-schoolers in the quiet, dysfunctional town of South Park, Colorado.
- CreatorMatt MaiellaroDave WillisStarsDave WillisCarey MeansDana SnyderThe misadventures of a milkshake, an order of fries, a meatball, and their retired next door neighbor in the suburbs of New Jersey.
- CreatorDino StamatopoulosStarsNathan BarnattVincent KartheiserT.J. MillerThe misadventures of the super-positive students of High School USA, as they confront all the unique, and often gross, challenges of growing up in a modern world.
- CreatorGreg DanielsMike JudgeStarsMike JudgeKathy NajimyPamela AdlonA straight-laced propane salesman in Arlen, Texas tries to deal with the wacky antics of his family and friends, while also trying to keep his son in line.
- CreatorGenndy TartakovskyStarsPhil LaMarrMakoKevin Michael RichardsonA samurai, sent through time, fights to return home and save the world.
- CreatorMike LazzoKhaki JonesStarsGeorge LoweC. Martin CrokerAndy MerrillSpace Ghost, a superhero from a 1960s Hanna-Barbera cartoon, hosts his own talk show.
- CreatorSeth MacFarlaneDavid ZuckermanStarsAlex BorsteinSeth MacFarlaneSeth GreenIn a wacky Rhode Island town, a dysfunctional family strives to cope with everyday life as they are thrown from one crazy scenario to another.
- CreatorDevin ClarkDavid M. SternStarsMatt ObergNatasha LeggeroKurt MetzgerTake New York City, add every horrifying beast, science-fiction freak, and fantasy faerie, shake thoroughly, and you've got Ugly Americans.
- CreatorBrad NeelyStarsAffion CrockettIlana GlazerDarrell HammondBrad Neely brings together and presents a humorous collection of chaotic and frantic "one-off" segments, as well as shorts and comedic songs.
- CreatorDan HarmonJustin RoilandStarsChris ParnellSpencer GrammerSarah ChalkeThe fractured domestic lives of a nihilistic mad scientist and his anxious grandson are further complicated by their inter-dimensional misadventures.
- CreatorBen HoffmanStarsJake JohnsonRon FunchesCleo KingCenters on a hot-headed, foul-mouthed high school basketball coach who thinks turning around his godawful team will take him to the "big leagues."
- CreatorJames L. BrooksMatt GroeningSam SimonStarsDan CastellanetaNancy CartwrightHarry ShearerThe satiric half-hour adventures of a working-class family in the misfit city of Springfield.
- CreatorMike BarkerSeth MacFarlaneMatt WeitzmanStarsSeth MacFarlaneWendy SchaalScott GrimesThe escapades of Stan Smith, a conservative C.I.A. Agent dealing with family life, and keeping America safe.
- CreatorAlex HirschStarsJason RitterAlex HirschKristen SchaalTwin siblings Dipper and Mabel Pines spend the summer at their great-uncle's tourist trap in the enigmatic Gravity Falls, Oregon.
- CreatorGlenn EichlerSusie LewisStarsTracy GrandstaffWendy HoopesJulian RebolledoA smart and cynical girl goes through teenage life as a proud outsider in a world of mainly idiotic adolescents and condescending adults.
- CreatorVan PartibleStarsJeff BennettBrenda VaccaroMae WhitmanThe misadventures of a dumb blond egomaniac who severely overestimates his own manliness and his supposed "success" with women.
- CreatorJace RichdaleAngus OblongStarsWill FerrellPamela AdlonJean SmartThe misadventures of a goofy family deformed by toxic waste.
- CreatorRichard AppelMike HenrySeth MacFarlaneStarsMike HenrySanaa LathanKevin Michael RichardsonCleveland Brown moves back to his hometown in Virginia, where he finds his high school sweetheart and her two troublemaking kids.
- CreatorMatt MariskaAndy SipesSean DonnellyStarsEric MagnussenDana SnyderJonah RayThe sickest, most twisted animated shorts ever put on television.
- CreatorNick ParkStarsPeter SallisAshley JensenJem StansfieldWallace introduces correspondents, inventors and experts who explain various real-life contraptions, inventions and scientific accomplishments.
- CreatorGenndy TartakovskyStarsKath SoucieJeff BennettChristine CavanaughThe misadventures of a boy genius and his annoying sister.
- CreatorDanny AntonucciStarsMatt HillSam VincentTony SampsonThe off-the-wall, day-to-day life of three friends who have exactly the same name.
- CreatorJennifer FlackettAndrew GoldbergNick KrollStarsNick KrollJohn MulaneyJessi KleinTeenage friends find their lives upended by the wonders and horrors of puberty.
- CreatorRoger BlackWaco O'GuinStarsDaniel ToshRoger BlackDavid HermanA group of never-do-well forest rangers are facing the shutdown of their National Park when a new ranger arrives to help transform them and save the park.
- CreatorBrad NeelyDaniel WeidenfeldDan PasternackStarsBrad NeelyGreta GerwigHulk HoganSteve and Frank Smith are brothers who teach the history department in the worst university in America.
- CreatorDave JeserMatt SilversteinJordan YoungStarsAdam CarollaJess HarnellAbbey McBrideA parody of reality shows cast with spoofs of several famous types of animated characters.
- CreatorMark HentemannStarsHank AzariaNicholas GonzalezJudah FriedlanderFollow two families living in a Southwest desert town on the United States-Mexico border and how these two families inevitably cross and are bound by friendship and conflict.
- CreatorEric FogelGordon BarnettStarsMaurice SchlaferLen MaxwellMills LaneCelebrities duel it out in a wrestling ring, the first one who dies loses.
- CreatorBill LawrencePhil LordChristopher MillerStarsWill FortePhil LordMichael McDonaldThe greatest minds of the world have been cloned, and are now attending high school together.