- Speaks fluent Greek.
- Her husband, Peter, is a real estate developer and a Chef/Restauranteur (Graduate of the Culinary institute of America).
- Graduated magna cum laude with a BFA in theatre from Point Park College in Pittsburgh. Family owns and runs a candy factory in Akron.
- Was considered for the lead for My Big Fat Greek Wedding (2002), but was pregnant at the time.
- Announced July 12, 2010 that she will not be reprising her role as "Detective Stella Bonasera" on the TV series, CSI: NY (2004), for the seventh season.
- Her first TV commercial was for Semicid contraceptive. Her agent (whom she still uses as a result of this) worked an "embarrassment clause" into her contract for the commercial, which has become standard for her ever since.
- At the 1986 Miss Ohio Pageant, she won a talent award in a three-way tie, and was eventually named first runner up to Miss Ohio 1986.
- She competed as "Miss Columbus" in The 1986 Miss Ohio Pageant (Miss America).
- While most of the CSI: NY (2004) cast is from New York, Kanakaredes is one of three exceptions. The others are Gary Sinise (who was born in Illinois) and Anna Belknap (who was born in Maine).
- Competed in Synchronized Swimming while at Ohio State, famous for its college Synchronized Swimming program.
- Met her husband when they were both students at Ohio State University.
- Is currently one of the stars on CSI: NY (2004), which was introduced in the CSI: Miami (2002) cross-over episode "MIA/NYC Nonstop." "Miami" star David Caruso was a popular cast member of NYPD Blue (1993), a series in which Melina made numerous guest appearances.
- Graduated from Firestone High School in Akron, Ohio.
- January 25, 2003: welcomed second daughter, Karina Eleni, born in Los Angeles.
- Attended high school with Angie Everhart.
- Daughter Zoe born 23 May 2000, weighing 7 lbs, 12 oz.
- Starring as Sally Bowles in "Cabaret" on Broadway in Studio 54. (July 2003)
- Graduated From Point Park College In Pittsburgh.
- Spokeswoman for Maybelline New York (2001)
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