- Became the first country female to have three consecutive number one hits from the same album. The hits in question were "Bye Bye, " "I'm Alright, " and "Stand Beside Me, " from the album "I'm Alright." (1999)
- Has 2 sons with her husband Chris Deffenbaugh - Noah Roger Deffenbaugh (b. January 19, 2009) and Jonah Christopher Deffenbaugh (b. January 11, 2012).
- Was raised in Holliston, Massachusetts, where she attended Holliston High School.
- June 2007: Engaged to businessman Chris Deffenbaugh. The couple plans to marry in the fall.
- (September 6, 2017) Jo Dee Messina's team revealed she had been diagnosed with cancer. All 2017 tour dates after October 7 are postponed as she undergoes treatments in the fall.
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