- With his second wife Flaminia Morandi he had a daughter, Camilla Costanzo (born in 1973), and a son, Saverio Costanzo.
- From 1983 to 1986 he lived with Simona Izzo, never married but considered by him as a wife.
- He is one of Italy's best known journalists.
- Since 2004 he and his current wife Maria De Filippi are the adoptive parents of Gabriele (born in 1992).
- Costanzo began his career as a journalist, first as a contributing writer to Paese Sera and then as managing editor of the weekly Grazia.
- Costanzo also wrote the screenplays for several films. In 1977 he wrote and directed his first and to these days last film, Melodrammore.
- Since 2011 he also collaborated with Radio Manà Manà.
- His most popular show, Bontà loro was a staple of RAI's programming but he was forced to resign after news broke that he was a member of the Propaganda 2 masonic lodge. Costanzo then moved to Silvio Berlusconi's main TV station Canale 5, where he hosted The Maurizio Costanzo Show.
- Parallel to his career as a journalist, he worked as a radio and TV host, where he became known for his subtle, low-profile irony.
- On 14 May 1993, Costanzo, who had expressed delight at the arrest of Sicilian Mafia boss Salvatore Riina, was almost killed by a bomb as he drove down a Rome street; 23 people were injured.
- Costanzo was artistic director of Canale 5 until 2009. In 2010 he returned to RAI, presenting the talk show Bontà sua.
- In the late 1970s, he was the founding editor of the newspaper L'Occhio.
- In 1966 he co-wrote the lyrics of the song "Se telefonando", which was popularized by Mina.
- Costanzo was the "communication-agent" (an aesthetical and rhetorical consultant for public appearances) of many Italian political leaders.
- He was a professor at the Università degli Studi Niccolò Cusano.
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