- Created superspy Matt Helm and wrote 27 novels featuring the character, beginning with Death of a Citizen in 1960 and ending with The Damagers in 1993. A final Helm novel, The Dominators, was completed several years ago and as of 2004 still awaits release.
- (1980) Novel: "Cruises with Kathleen"
- (1980) Novel: "The Mona Intercept"
- (1970) Nonfiction book: "On Guns and Hunting"
- (1967) Collection (Donald Hamilton: Editor): Iron Men and Silver Stars
- (1960) Novel: "Texas Fever"
- (1960) Novel: "The Man From Santa Clara"
- Novel: "The Big Country", 1958 (filmed as The Big Country (1958))
- (1956) Novel: "Assignment: Murder" (aka "Assassins Have Starry Eyes")
- (1956) Novel: "Mad River"
- (1955) Novel: "Line of Fire"
- (1954) Novel: "Night Walker"
- (1954) Novel: "Smoky Valley" (filmed as The Violent Men (1955))
- (1950) Collection: Murder Twice Told (includes the novellas "The Black Cross" and "Deadfall")
- (1948) Novel: "The Steel Mirror" (filmed as 5 Steps to Danger (1956))
- (1947) Novel: "Date With Darkness"
- Novel (featuring Matt Helm): "The Dominators" (unpublished; Hamilton was revising the manuscript at the time of his death).
- (1993) Novel (featuring Matt Helm): "The Damagers"
- (1992) Novel (featuring Matt Helm): "The Threateners"
- (1989) Novel (featuring Matt Helm): "The Frighteners"
- (1987) Novel (featuring Matt Helm): "The Demolishers"
- (1986) Novel (featuring Matt Helm): "The Vanishers"
- (1985) Novel (featuring Matt Helm): "The Detonators"
- (1984) Novel (featuring Matt Helm): "The Infiltrators"
- (1983) Novel (featuring Matt Helm): "The Annihilators"
- (1982) Novel (featuring Matt Helm): "The Revengers"
- (1977) Novel (featuring Matt Helm): "The Terrorizers"
- (1976) Novel (featuring Matt Helm): "The Retaliators"
- (1975) Novel (featuring Matt Helm): "The Terminators"
- (1974) Novel (featuring Matt Helm): "The Intimidators"
- (1972) Novel (featuring Matt Helm): "The Intriguers"
- (1971) Novel (featuring Matt Helm): "The Poisoners"
- (1969) Novel (featuring Matt Helm): "The Interlopers"
- (1968) Novel (featuring Matt Helm): "The Menacers"
- (1966) Novel (featuring Matt Helm): "The Betrayers"
- (1965) Novel (featuring Matt Helm): "The Devastators"
- (1964) Novel (featuring Matt Helm): "The Ravagers"
- (1964) Novel (featuring Matt Helm): "The Shadowers"
- (1963) Novel (featuring Matt Helm): "The Ambushers" (filmed as The Ambushers (1967))
- (1962) Novel (featuring Matt Helm): "Murderers' Row" (filmed as Murderers' Row (1966))
- (1962) Novel (featuring Matt Helm): "The Silencers" (filmed as The Silencers (1966))
- (1961) Novel (featuring Matt Helm): "The Removers"
- (1960) Novel (featuring Matt Helm): "The Wrecking Crew" (filmed as The Wrecking Crew (1968))
- (1960) Novel (featuring Matt Helm): "Death of a Citizen" (filmed as The Silencers (1966))
- (6/46) Story: "Stranger's Return"
- (11/46) Short Story: "Magnolia"
- (6/51) Story: "Mask for Danger"
- (August 1953) Short Story: "Throwback"
- (May 1955) Short Story: "Too Soon Dead"
- (February 1957) Story: "Ambush at Blanco Canyon"
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