- Wrote the Megadeth song "In My Darkest Hour" in reaction to hearing the news about the death of Metallica bassist Cliff Burton.
- Godson of Alice Cooper.
- The Megadeth song "Something I'm Not" (from the 2004 album "The System Has Failed") is about Lars Ulrich's "betrayal" of Dave.
- In 2002, he suffered a nerve injury to his left arm, which he said resulted from falling asleep with that arm over the back of a chair. He disbanded Megadeth that year, only to reform it in 2004 after extensive physical therapy for the injury.
- Former lead guitarist of Metallica. His drinking habits led to his 1983 dismissal from the band, a move Mustaine referred to as having "no warning, no second chance".
- Considers Dave Gilmour's guitar solo in 'Time' by Pink Floyd as his favorite.
- Was notorious for his feuds with members of Metallica and Slayer, but by 2010 these feuds subsided.
- Diagnosed with throat cancer in May 2019. He underwent 51 radiation treatments and nine chemotherapy sessions before announcing he was cancer-free in January 2020.
- Has a son, Justis David, and a daughter, Electra Nicole
- Recovered from arm injury and recorded "The System Has Failed" as a solo project but, due to contractual issues, released it under the name of Megadeth (September 2004).
- The song "Liar" from Megadeth's "So Far So Good So What" (1988) album was written by Mustaine about Chris Poland, the guitarist he had recently been forced to fire from the band.
- He was a heavy smoker for many years.
- The only member of Megadeth to appear on every one of the band's recordings.
- Lives in Fallbrook and Oceanside, California.
- The new album "United Abominations" from Megadeth is now released. 'Christina Scabbia' from Lacuna Coil is guest vocalist on the song "A Tout Le Monde". (May 2007)
- Underwent back surgery in September 2011, after suffering from spinal stenosis. His back problems were at least partly due to a history of aggressive rock performances.
- Founder, guitarist and lead singer of Megadeth.
- In 1992 covered the Democratic National Convention for MTV News
- Is currently on "Tour of Duty" (October 2007)
- Headlining the metal festival "Gigantour". But still has dates to complete on Megadeth's "Blackmail the Universe Tour". (August 2005)
- According to Metallian. Com Dave Mustaine forced the group Rotting Christ from a festival bill.
- Endorsed far right politician Rick Santorum for President of the United States of America. Santorum dropped out.
- Sex Pistols withdrew the permission for Megadeth to perform Anarchy In The UK after singer and guitarist Mustaine altered the lyrics to commercialize the lyrics.
- Seller of NFT and Crypto wares.
- According to PRP, David Mustaine reported he had urinated on the White House floor in order to prove that he is not stupid.
- Still selling NFTs and cryptocurrency to fans as of 2023.
- Corporation that engages in merchandising.
- Melania Trump and David Mustaine hawk crypto and NFT.
- Part of a fraternity of NFT sellers with Melania Trump.
- Dave Mustaine is a birther.
- According to PRP, takes bands he, or his son, manages on tour as openers.
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