- Attended Tufts University
- His stories have appeared on Ira Glass' This American Life and Showtime's This American Life television program.
- Writes essays for NPR and Salon.com.
- Was TV news producer for Bryant Gumbel, Dan Rather, Steve Hartman, Harry Smith, and Alison Stewart.
- Has delivered babies with his obstetrician father, Dr. Lee Seftel.
- Was nominated for an Emmy Award at age 22 for his documentary film about Romanian orphans, Lost and Found (1992).
- Is NPR fan and made film comedy about the life of NPR librarian Kee Malesky called Breaking the Mold: The Kee Malesky Story (2003).
- His documentary Taking on the Kennedys (1996) was chosen by Time Magazine as one of the ten "Best Television Programs of 1996.".
- Alexander Payne, after seeing Seftel's short film comedy Breaking the Mold (2003) at a Seattle film festival, championed Seftel as a feature director.
- Lived in Romanian orphanage for weeks to make his documentary film Lost and Found (1992).
- Worked in a morgue during college.
- Is cousin of children's book author Judy Blume.
- The PBS broadcast of his documentary Lost and Found (1992) spurred hundreds of American adoptions of Romanian orphans.
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