- Co-founded the charitable organization IBG, along with fellow entertainment professionals Elizabeth De Razzo, Danielle Turchiano, Patricia Steffy, and Karen Mendez. The non-profit raised money for underfunded causes while promoting philanthropy through the arts. It ran from 2008 - 2014.
- Studied French, German, Latin, and American Sign Language in school. Also knows some Irish Gaelic and Hebrew.
- Originally setting her sights on a dance career until the age of 12, Scott studied ballet, tap, and jazz in her youth. She was also very involved in music, playing the viola, cello, flute, oboe, and piano at a young age.
- Was discovered by a modeling agency at the age of 14, and has modeled both print and runway on and off ever since.
- She is of Irish descent on her father's side and French-German descent on her mother's side.
- She is an active and outspoken member of the Democratic Party.
- Graduated in the top 5% of her high school class.
- Her mother is godmother to Iggy Pop's son, Eric.
- Her father was close friends with late actor Dennis Pfister.
- She is a descendant of Germany's noble House of Hohenzollern and holds the title of Lady in the United Kingdom and its territories.
- Her uncle is cinematographer Peter Herb.
- In a relationship with Erik Carabasi from 2010 - 2016. The pair collaborated on Altered Reality (2016) and Parts of Disease (2013).
- Used to wait tables with Camilla Luddington.
- Has an IQ of 140.
- She served as a lead volunteer organizer for 18 months on Hillary Clinton's 2016 Presidential campaign, and was a founding member of the Young Leaders Council for Kirsten Gillibrand's 2020 Presidential campaign.
- She is a gun crime survivor and publicly advocates and lobbies for sensible gun legislation.
- She is a competitive equestrian and archer.
- Her longtime family friends and colleagues include musician Johnny J. Blair and late musicians Steve Mitchell (the inspiration for Jim Henson's character, Animal) and Davy Jones.
- She is a friend and collaborator of Cristina Cacciotti, daughter of the late Valerie Harper.
- Romantically linked to creative collaborator Paulo Netto from 2019 - 2022.
- She publicly advocates for a ban on the cruel and abusive horse racing industry.
- She has been the face of volunteerism for Motion Picture & Television Fund since 2014, the face of Planned Parenthood of New York City's Votes PAC since 2018, appeared in an ad campaign for Get In Touch Foundation's breast self-exam app launch in 2019, and appeared in a digital ad campaign for social awareness brand Shop Social Goods in 2020.
- Good friends with producer/director Barclay DeVeau, who has directed her in several theatrical pieces featuring Kathleen Turner for Take The Lead, an organization by Gloria Feldt dedicated to achieving gender leadership parity. She also appeared in DeVeau's staged reading of "12 Angry Men" performed by 12 Impassioned Womxn for the 12,000 Voices Initiative, raising money for several voting rights organizations, including The League of Women Voters, Voto Latino, and When We all Vote.
- Conan O'Brien gave her an impromptu hug during the monologue in the first episode of Conan (2010), creating a trend during the show's first season.
- Met good friend and collaborator, producer Tom D'Angora, in 2015 when both were working on Hillary Clinton's presidential campaign, headquartered in Brooklyn, NY.
- Along with Girlcrush Comedy partner Jacklyn Collier, produced Broadway Babes for Planned Parenthood, which debuted at Don't Tell Mama starring Sydnee Washington, Emily Lynne, Josephine Patane, Jillian Gottlieb, Analisa Leaming, Catherine Landeta, and Shawlini Manjunath-Holbrook.
- On April 18, 2022, she announced her breast cancer diagnosis via a photo essay in collaboration with Paulo Netto.
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