Sort by Popularity - Most Popular Movies and TV Shows tagged with keyword "fictional-drug"
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51. Naked Lunch (1991)
R | 115 min | Drama, Mystery
After developing an addiction to the substance he uses to kill bugs, an exterminator accidentally kills his wife and becomes involved in a secret government plot being orchestrated by giant bugs in a port town in North Africa.
Director: David Cronenberg | Stars: Peter Weller, Judy Davis, Ian Holm, Julian Sands
Votes: 56,901 | Gross: $2.54M
52. Bringing Out the Dead (1999)
R | 121 min | Drama, Thriller
Haunted by the patients he failed to save, a monumentally burned-out Manhattan ambulance paramedic fights to maintain his sanity over three increasingly turbulent nights.
Director: Martin Scorsese | Stars: Nicolas Cage, Patricia Arquette, John Goodman, Ving Rhames
Votes: 76,407 | Gross: $16.64M
53. Southland Tales (2006)
R | 145 min | Comedy, Drama, Mystery
During a three-day heat wave just before a huge 4th of July celebration, an action star stricken with amnesia meets up with a porn star who is developing her own reality TV project, and a policeman who holds the key to a vast conspiracy.
Director: Richard Kelly | Stars: Dwayne Johnson, Sarah Michelle Gellar, Seann William Scott, Carlos Amezcua
Votes: 40,716 | Gross: $0.28M
54. Outland (1981)
R | 109 min | Action, Crime, Sci-Fi
A federal marshal stationed at a mining colony on the Jupiter moon of Io uncovers a drug-smuggling conspiracy. He gets no help from the workers or authorities when he finds himself marked for murder.
Director: Peter Hyams | Stars: Sean Connery, Frances Sternhagen, Peter Boyle, James Sikking
Votes: 32,498 | Gross: $17.37M
55. Osmosis Jones (2001)
PG | 95 min | Animation, Action, Adventure
A policeman white blood cell, with the help of a cold pill, must stop a deadly virus from destroying the human they live in, Frank.
Directors: Bobby Farrelly, Peter Farrelly | Stars: Laurence Fishburne, Chris Rock, David Hyde Pierce, Brandy Norwood
Votes: 38,898 | Gross: $13.60M
56. Max Payne (2008)
PG-13 | 100 min | Action, Crime, Drama
Coming together to solve a series of murders in New York City are a police detective and an assassin, who will be hunted by the police, the mob, and a ruthless corporation.
Director: John Moore | Stars: Mark Wahlberg, Mila Kunis, Beau Bridges, Ludacris
Votes: 130,359 | Gross: $40.69M
57. The 4400 (2004–2007)
TV-14 | 43 min | Drama, Mystery, Sci-Fi
As the reappearance of 4,400 missing persons on a single day confounds the global community, federal agents on the case slowly discover the ways in which the victims have been changed.
Stars: Jacqueline McKenzie, Joel Gretsch, Patrick John Flueger, Conchita Campbell
Votes: 46,963
58. Get Him to the Greek (2010)
R | 109 min | Comedy, Music
A record company intern is hired to accompany out-of-control British rock star Aldous Snow to a concert at L.A.'s Greek Theater.
Director: Nicholas Stoller | Stars: Jonah Hill, Russell Brand, Elisabeth Moss, Rose Byrne
Votes: 185,936 | Gross: $60.97M
59. Synchronic (2019)
R | 102 min | Drama, Horror, Mystery
Two New Orleans paramedics' lives are ripped apart after they encounter a series of horrific deaths linked to a designer drug with bizarre, otherworldly effects.
Directors: Justin Benson, Aaron Moorhead | Stars: Anthony Mackie, Jamie Dornan, Katie Aselton, Ally Ioannides
Votes: 40,451
60. Junior (1994)
PG-13 | 109 min | Comedy, Romance, Sci-Fi
As part of a fertility research project, a male scientist agrees to carry a pregnancy in his own body.
Director: Ivan Reitman | Stars: Arnold Schwarzenegger, Danny DeVito, Emma Thompson, Frank Langella
Votes: 73,198 | Gross: $36.76M
61. Dark Angel (1990)
R | 91 min | Action, Crime, Horror
A Renegade Cop is forced to work with an FBI Agent in order to bring down a group of Drug Dealers with sinister plans.
Director: Craig R. Baxley | Stars: Dolph Lundgren, Brian Benben, Betsy Brantley, Matthias Hues
Votes: 14,024 | Gross: $4.35M
62. Repo! The Genetic Opera (2008)
R | 98 min | Horror, Musical, Sci-Fi
A worldwide epidemic encourages a biotech company to launch an organ-financing program similar in nature to a standard car loan. The repossession clause is a killer, however.
Director: Darren Lynn Bousman | Stars: Paul Sorvino, Anthony Head, Alexa PenaVega, Sarah Brightman
Votes: 26,614 | Gross: $0.14M
63. Derailed (I) (2005)
R | 108 min | Crime, Drama, Thriller
When two married business executives having an affair are blackmailed by a violent criminal, the two must turn the tables on him to save their families.
Director: Mikael Håfström | Stars: Clive Owen, Jennifer Aniston, Vincent Cassel, Addison Timlin
Votes: 76,514 | Gross: $36.02M
64. John Dies at the End (2012)
R | 99 min | Comedy, Fantasy, Horror
A new street drug that sends its users across time and dimensions has one drawback: some people return no longer human. Can two college drop-outs save humanity from this silent, otherworldly invasion?
Director: Don Coscarelli | Stars: Chase Williamson, Rob Mayes, Paul Giamatti, Clancy Brown
Votes: 40,452 | Gross: $0.14M
65. Class of 1999 (1990)
R | 99 min | Action, Horror, Sci-Fi
Three ex-military robots are reprogrammed as teachers and secretly placed in a school where most students are part of organized gangs. They begin to respond violently to unruly students, and their military training starts to take over.
Director: Mark L. Lester | Stars: Bradley Gregg, Traci Lind, Malcolm McDowell, Stacy Keach
Votes: 8,704 | Gross: $2.46M
66. The Happytime Murders (2018)
R | 91 min | Action, Comedy, Crime
When the puppet cast of a '90s children's TV show begin to get murdered one by one, a disgraced LAPD detective-turned-private eye puppet takes on the case.
Director: Brian Henson | Stars: Melissa McCarthy, Elizabeth Banks, Maya Rudolph, Leslie David Baker
Votes: 30,438 | Gross: $20.71M
67. Kite (2014)
R | 90 min | Action, Crime, Thriller
After her cop father is killed, a young woman tracks the murderer down with the help of his ex-partner.
Director: Ralph Ziman | Stars: India Eisley, Jaco Muller, Annabel Linder, Christina Storm
Votes: 6,752
68. Cowboy Bebop: The Movie (2001)
TV-14 | 115 min | Animation, Action, Crime
A terrorist explosion releases a deadly virus on the masses, and it's up to the bounty-hunting Bebop crew to catch the cold-blooded culprit.
Directors: Shin'ichirô Watanabe, Mary Elizabeth McGlynn, Tensai Okamura, Hiroyuki Okiura, Yoshiyuki Takei | Stars: Beau Billingslea, Melissa Fahn, Nicholas Guest, Kôichi Yamadera
Votes: 53,426 | Gross: $1.00M
69. Suburbia (1983)
R | 94 min | Drama, Thriller
When household tensions and a sense of worthlessness overcome Evan, he finds escape when he clings with the orphans of a throw-away society.
Director: Penelope Spheeris | Stars: Chris Pedersen, Bill Coyne, Jennifer Clay, Timothy O'Brien
Votes: 6,059
70. Liquid Sky (1982)
R | 112 min | Sci-Fi, Thriller
A small, heroin seeking UFO lands on a Manhattan roof, observes a bizarre, drug addicted fashion model and sucks endorphin from her sexual encounters' brains.
Director: Slava Tsukerman | Stars: Anne Carlisle, Paula E. Sheppard, Susan Doukas, Otto von Wernherr
Votes: 6,901
71. The Education of Fredrick Fitzell (2020)
R | 97 min | Drama, Mystery, Thriller
After a chance encounter with a man forgotten from his youth, Fred literally and metaphorically journeys into his past.
Director: Christopher MacBride | Stars: Dylan O'Brien, Liisa Repo-Martell, Maika Monroe, Hannah Gross
Votes: 7,174
72. Alien Nation (1988)
R | 91 min | Action, Sci-Fi
In 1988, Earth makes the first contact with an alien civilization. In 1991, these aliens, known as Newcomers, slowly begin to be integrated into human society after three years of quarantine.
Director: Graham Baker | Stars: James Caan, Mandy Patinkin, Terence Stamp, Kevyn Major Howard
Votes: 16,711 | Gross: $25.22M
73. Formula 51 (2001)
R | 93 min | Action, Comedy, Crime
An American master chemist plans to score big on a once in a lifetime drug deal. All does not go as planned and he is soon entangled in a web of deceit.
Director: Ronny Yu | Stars: Samuel L. Jackson, Robert Carlyle, Emily Mortimer, Nigel Whitmey
Votes: 51,050 | Gross: $5.20M
74. Attack of the 50 Foot Cheerleader (2012)
R | 83 min | Adventure, Comedy, Romance
Aspiring college cheerleader Cassie Stratford consumes an experimental drug that grants her beauty and enough athletic ability to make the cheer squad. It has an unforeseen side effect - she starts to grow and grow and grow.
Director: Kevin O'Neill | Stars: Jena Sims, Sean Young, Treat Williams, Sasha Jackson
Votes: 1,593
75. Bride of Re-Animator (1990)
R | 96 min | Comedy, Horror, Sci-Fi
Doctors Herbert West and Dan Cain discover the secret to creating human life and proceed to create a perfect woman from dead tissue.
Director: Brian Yuzna | Stars: Jeffrey Combs, Bruce Abbott, Claude Earl Jones, Fabiana Udenio
Votes: 17,686
76. Senseless (1998)
R | 93 min | Comedy, Romance
A student gets his senses enhanced by an experimental drug. But abuse is not an option.
Director: Penelope Spheeris | Stars: Marlon Wayans, David Spade, Brad Dourif, Esther Scott
Votes: 17,801 | Gross: $13.04M
77. The Wonderpill (2015)
82 min | Comedy, Drama, Romance
A young woman suffers from heavy migraines. Her boyfriend tricks her into taking a fake pill to treat her migraines; side effect: an exploding libido.
Director: Mannyx Guillen | Stars: Dina Smirnoff, Jeffry Mora, Gus Ferrari, Tiffany James
Votes: 123
78. Zulu (2013)
R | 110 min | Action, Crime, Drama
Policemen Ali Sokhela and Brian Epkeen investigate the brutal murder of a young white woman, apparently provoked by the availability of a new illegal drug and somehow connected to the disappearance of black street children.
Director: Jérôme Salle | Stars: Orlando Bloom, Forest Whitaker, Conrad Kemp, Inge Beckmann
Votes: 19,886
79. Cheech and Chong's Next Movie (1980)
R | 99 min | Comedy, Crime
Cheech and Chong live in a decrepit old house and drive their neighbour crazy with their loud music, weed smoking and general anarchy and slacker view on life. Then Chong meets Cheech's Texan cousin Red and things kick up a notch.
Director: Tommy Chong | Stars: Cheech Marin, Tommy Chong, Evelyn Guerrero, Betty Kennedy
Votes: 15,004 | Gross: $41.68M
80. Go Goa Gone (2013)
Not Rated | 111 min | Action, Adventure, Comedy
A group of friends, just looking to have a good time in a rave party on a remote island in Goa, find out that the island is infested with Zombies.
Directors: Krishna D.K., Raj Nidimoru | Stars: Saif Ali Khan, Kunal Kemmu, Vir Das, Anand Tiwari
Votes: 15,412 | Gross: $0.30M
81. Twelve (2010)
R | 93 min | Action, Drama, Thriller
A young drug dealer watches as his high-rolling life is dismantled in the wake of his cousin's murder, which sees his best friend arrested for the crime.
Director: Joel Schumacher | Stars: Chace Crawford, Emma Roberts, Rory Culkin, Philip Ettinger
Votes: 12,683 | Gross: $0.18M
82. Heavy Rain (2010 Video Game)
M | Crime, Drama, Mystery
As a child goes missing, his father tirelessly works to rescue him, while a journalist, an FBI agent, and a private detective try to identify his kidnapper known only as the "Origami Killer".
Director: David Cage | Stars: Pascal Langdale, Jacqui Ainsley, Judi Beecher, Sam Douglas
Votes: 14,909
83. Gangsta. (2015)
TV-MA | 24 min | Animation, Action, Drama
Two handymen take on jobs for both the mob and the police that no one else can handle. Worick and Nicolas work in a town which is full of mafia, hoodlums and prostitutes. They face a challenge after taking on a job of crushing a gang
Stars: Mamiko Noto, Felecia Angelle, Jun'ichi Suwabe, Kenjirô Tsuda
Votes: 3,460
84. Brave New World (1998 TV Movie)
87 min | Drama, Sci-Fi
In a futuristic totalitarian utopian society, babies are created through genetic engineering, everyone has a predestined place in society and their minds are conditioned to follow the rules. A tragic outsider jeopardizes the status quo.
Directors: Leslie Libman, Larry Williams | Stars: Peter Gallagher, Leonard Nimoy, Tim Guinee, Rya Kihlstedt
Votes: 2,152
85. Beyond Re-Animator (2003)
R | 96 min | Comedy, Horror, Sci-Fi
After 13 years in prison, the mad scientist from Re-Animator (1985) gets a new chance to experiment with the arrival of a young prison doctor, who secretly hopes to learn to reanimate dead people. Good intentions turn to horror.
Director: Brian Yuzna | Stars: Jeffrey Combs, Tommy Dean Musset, Jason Barry, Bárbara Elorrieta
Votes: 13,078
86. Bad Blood (1986)
Unrated | 105 min | Crime, Drama, Romance
As a deadly virus which infects people who have loveless sex sweeps Paris, a lonely pariah attempts to steal a potent antidote, only to fall for the mistress of his partner-in-crime. Is the infectious young love the cure to the bad blood?
Director: Leos Carax | Stars: Michel Piccoli, Juliette Binoche, Denis Lavant, Hans Meyer
Votes: 9,368 | Gross: $0.02M
87. Prayer of the Rollerboys (1990)
R | 95 min | Action, Crime, Drama
In a dystopian near future America, a young man infiltrates a powerful drug dealing rollerblading youth gang that runs his town in order to end their reign for good.
Director: Rick King | Stars: Corey Haim, Patricia Arquette, Christopher Collet, Julius Harris
Votes: 2,785
88. How I Became a Super Hero (2020)
TV-MA | 97 min | Action, Adventure, Comedy
While superheroes have assimilated into Parisian society, a new drug gives super powers to mere mortals.
Director: Douglas Attal | Stars: Pio Marmaï, Vimala Pons, Benoît Poelvoorde, Leïla Bekhti
Votes: 6,133
89. The Wasp Woman (1959)
Not Rated | 63 min | Horror, Sci-Fi
The head of a major cosmetics company experiments on herself with a youth formula made from royal jelly extracted from wasps, but the formula's side effects have deadly consequences.
Director: Roger Corman | Stars: Susan Cabot, Anthony Eisley, Barboura Morris, William Roerick
Votes: 5,528
90. Higurashi: When They Cry - GOU (2020–2021)
TV-MA | Animation, Drama, Horror
Keiichi Maebara is in his new home in the peaceful Hinamizawa village, making friends with girls from school. He's here for a big festival. But something about this town seems off, with that fear what dark secrets can this small town hide?
Stars: Sôichirô Hoshi, Yukari Tamura, Mai Nakahara, Emi Lo
Votes: 796
91. Unforgettable (1996)
R | 117 min | Drama, Mystery, Sci-Fi
A Seattle medical examiner uses an experimental memory transference drug to unravel the mystery surrounding his Wife's brutal murder.
Director: John Dahl | Stars: Ray Liotta, Linda Fiorentino, Peter Coyote, Christopher McDonald
Votes: 6,027 | Gross: $2.78M
92. Brave New World (1980 TV Movie)
180 min | Drama, Sci-Fi
A man who grew up in a primitive society educating himself by reading Shakespeare is allowed to join the futuristic society where his parents are from. However, he cannot adapt to their repressive ways.
Director: Burt Brinckerhoff | Stars: Julie Cobb, Bud Cort, Keir Dullea, Ron O'Neal
Votes: 1,154
93. Kids in the Hall: Brain Candy (1996)
R | 89 min | Comedy
A pharmaceutical scientist creates a pill that makes people remember their happiest memory, and although it's successful, it has unfortunate side effects.
Director: Kelly Makin | Stars: Dave Foley, Bruce McCulloch, Kevin McDonald, Mark McKinney
Votes: 9,499 | Gross: $2.65M
94. Tell Me How I Die (2016)
Not Rated | 107 min | Horror, Mystery, Thriller
A9913 is a new drug improving memory - like being there again. Anna joins 17 others testing it for $2000. Some experience the near future including deaths.
Director: D.J. Viola | Stars: Nathan Kress, Virginia Gardner, Kirby Bliss Blanton, Ryan Higa
Votes: 5,312
95. Body Melt (1993)
Not Rated | 81 min | Horror, Comedy, Sci-Fi
Residents of peaceful Pebbles Court, Homesville, are being used unknowingly as test experiments for a new 'Body Drug' that causes rapid body decomposition (melting skin etc.) and painful death.
Director: Philip Brophy | Stars: Gerard Kennedy, Andrew Daddo, Ian Smith, Regina Gaigalas
Votes: 3,739
96. Horror High (1973)
PG | 85 min | Horror
A shock-filled tale of a serious and shy but brilliant science student who, when wrongfully forced to consume a new drug he'd created, becomes a modern day Jekyll and Hyde.
Director: Larry N. Stouffer | Stars: Pat Cardi, Austin Stoker, Rosie Holotik, John Niland
Votes: 1,187
97. Mutant Hunt (1987 Video)
Not Rated | 75 min | Action, Sci-Fi
Z, a vicious genetic scientist, discovers a way to alter harmless humanoid androids called 'Cyborgs' into becoming killing machines, which he plans to use for his own gain.
Director: Tim Kincaid | Stars: Rick Gianasi, Mary Fahey, Ron Reynaldi, Taunie Vrenon
Votes: 834
98. Wonderland (2011)
Unrated | 80 min | Action, Fantasy, Horror
A new drug grants its users the ability to place their consciousness into the bodies of other people. Soon, a serial killer begins to use the drug as a way to live and die as other people by forcing his victims to kill themselves.
Director: Brandon Slagle | Stars: Keith Kraft, Devanny Pinn, Rachel Grubb, Brandon Slagle
Votes: 370
99. Ares (2016)
80 min | Drama, Sci-Fi, Thriller
In a future France with many unemployed, big companies run the country. Ares is a loser boxer. When his sister's arrested, he agrees to a new drug, that'll help him win.
Director: Jean-Patrick Benes | Stars: Ola Rapace, Micha Lescot, Thierry Hancisse, Hélène Fillières
Votes: 4,502
100. The Fix (VIII)
Action, Sci-Fi | Completed
In a dystopian future where air is toxic, a troubled young model takes an illicit new drug at a party and suffers a shocking transformation. She undertakes to reverse the effects of the ... See full summary »
Director: Kelsey Egan | Stars: Grace Van Dien, Daniel Sharman, Aidan Scott, Chris Fisher