In a pure "pre-Code" moment, we see Sister Fallon's chauffeur, Lou, give Hornsby "the finger" (out of Horsby's sight) immediately after Hornsby warns him about what he must do to keep his job. The Hays Office surely would have rejected this scene had the movie been made after 1934.
Barbara Stanwyck had only one day of rest between the completion of this movie and the first day's shooting of Night Nurse (1931).
The character of Florence Fallon was largely based on popular evangelist preacher Aimee Semple McPherson. Some people nicknamed her "The Miracle Woman" because of her supposed healing powers, but others derided her as a fraud and con artist, saying she never "cured" anyone and was just using the pulpit to make money.
The play "Bless You, Sister," by John Meehan & Robert Riskin, opened in New York on 26 December 1927 and closed in January 1928 after 28 performances. The opening night cast included George Alison, Robert Ames, Charles Bickford, Alice Brady, Dennis Gurney and George Lessey.