Another reviewer noted that the setting for this 1943 movie was 1938, a few years before the U.S. got into World War II. Life went on in time of war in the U.S., and Hollywood made many comedies to help relieve the home front stress and worry about the war. But the country also had rationing, reduced use of gas, and other product restrictions. So, it's not too likely that there were many bus tours around the country, as in this film. And, if there were some, the movie industry wouldn't want to be put on the spot encouraging Americans to splurge in a time of shortage. So, the time of the film taking place was just set back a few years.
"A Lady Takes a Chance" is a fun comedy romance that paired a couple of unlikely stars. Jean Arthur was one of the top female movie comics of the time, and John Wayne was known then for his long string of mostly Westerns. Wayne had ventured into comedy once before, in "His Private Secretary" (1933), and I think he did quite well. This movie showed that he could do comedy well – especially as a straight man against a comic partner.
The Arthur-Wayne pairing works very well in this movie. The Western and war film fans of John Wayne should enjoy this comedy-romance as well.