This was Lex Barker's fifth and final appearance as Tarzan. He spent much of the rest of his film career making movies in Europe, where his having played Tarzan (and his marriage to Lana Turner) had made him a household name.
Normally quite hairy-chested, Barker was forced to submit to a full body wax in order to play the buffed version of Tarzan demanded by the producers. It was not until he abandoned the Tarzan role and went to Europe to film that his fans were finally allowed to see him as nature intended, with his chest hair intact.
At the time he made this film, Raymond Burr's career was on the ascent. The following year, he played the villain Thorwald in Hitchcock's Rear Window, and starred in the English language material shot for the U.S. release of Godzilla. In 1958, he was cast as his best-remembered character, the title role in the long-running CBS series Perry Mason.
Monique van Vooren, who plays Lyra (the "She Devil" of the film's title) appears here as a brunette, though she spent most of her film career as a blonde. It is unclear if it was because of problems with recording equipment, or van Vooren's obvious lack of acting talent, but almost every line she speaks in this film has clearly had to be looped.
This was the fifth Tarzan film for Lex Barker, and features the fifth different actress to play Jane opposite him. After Gordon Scott took over the role of The Ape Man in the next film in this franchise (Tarzan's Hidden Jungle) the role of Jane was not even included.