Paisano Construction Company, seen on a placard outside the Leaning Tower of Pisa, might have been a wink at Paisano Productions, that was behind the popular TV series Perry Mason (1957). The actual definition of paisano is a peasant of Spanish or Italian origin.
This cartoon is mostly made up of clips from previous cartoons: Tweety's S.O.S. (1951) (the boat scene), Tree Cornered Tweety (1956) (the skiing and bridge scenes), Tweet Tweet Tweety (1951) (the swinging scene), and A Pizza Tweety-Pie (1958) (the ending in the restaurant). The only unique footage is when Granny is shown the brochures, the finger painting scene, when Granny says "I'm all ready, Tweety. I'll meet you at the ski lift.", and the initial part of the Japan scene (everything before Tweety making it to the bridge).
The age of jet travel was just around the corner as this short was released. Boat and rail journeys were still the norm.
Granny's portrait of her finger would be nodded to by Harry Morgan, as Colonel Sherman Potter, in the M*A*S*H TV series (1972).