This film marks the first collaboration between Mario Bava and his son/assistant director Lamberto Bava. Lamberto would later become a director himself.
Director Mario Bava used the mirror-based Schufftan Process to combine live action with miniatures and thereby avoiding the costly matte/optical printing techniques.
This film went through fifteen working titles before American International Pictures settled on "Planet of the Vampires."
Only one spaceship model was built for this film.
The original title for this film during production was "Planet of Terror."