The character Oscar North was openly used as the pattern for Ted Baxter on the Mary Tyler Moore, which Leonard Stern, creator of this series, granted permission. Jack Cassidy, the star of this show, played Ted's brother Hal in one episode, Cover Boy (1971).
Co-stars Richard Benjamin and Paula Prentiss were married in real life. They married in 1961 and, as of this writing (2021), are still married.
"He & She" is widely considered by broadcast historians to have been ahead of its time. Its sophisticated approach to comedy was viewed as opening doors to the groundbreaking MTM family of sitcoms of the 1970s, beginning with "The Mary Tyler Moore Show" in 1970. Allan Burns, co-writer and story editor for "He & She", went on to co-create and write for "The Mary Tyler Moore Show".
Paula Prentiss accepted this role because she felt it would be therapeutic as an nonthreatening way to ease back into acting after a she suffered a nervous breakdown on the set of 1965's "What's New, Pussycat?", which virtually derailed her career for awhile.
Prior to this series, TV was swelling up with way out fantasy sitcoms and shows like "Bewitched "(1964), "I Dream of Jeannie" (1965), and "Batman" (1966). "He & She" was an attempt to bring a more intelligent approach to comedy.