For this film, directed by and starring Charlton Heston, the second unit director is Joe Canutt. Canutt was Heston's stunt stand-in for Ben-Hur (1959), most notably during the famous chariot race.
This marked the third and final time that Charlton Heston played Mark Antony. He previously did so in Julius Caesar (1950) and Julius Caesar (1970).
Charlton Heston wanted to cast Diana Rigg, who had co-starred with him in Julius Caesar (1970), as Cleopatra.
Three of the Spanish actors appearing in small supporting roles were dubbed by Richard Johnson without a fee, as a favor to his friend Charlton Heston.