The show launched the careers of comedians Ben Elton, Harry Enfield, Stephen Fry and Hugh Laurie.
The show was influenced by NBC's Saturday Night Live (1975).
Rowan Atkinson and Angus Deyton performed the song "I, Believe", which was the song Rowan Atkinson sung with Mel Smith, Griff Rhys-Jones and Pamela Stevenson on Not the 9 O'clock News (1982).
Some of the gags in The Dangerous Brothers was later reused in Rik Mayall and Adrian Edmondson's sitcom Bottom (1991).
A Dangerous Brothers sketch entitled "Kinky Sex" was filmed, but did not get broadcast which saw Sir Adrian come home only to find Richie is wearing a nurse's uniform and that a prostitute is hiding in his wardrobe and Sir Adrian reveals that he has brought 3 prostitutes home himself.