A new enemy called the Death Busters appears, an organization whose members aim to get their hands on the talismans that can only be found in pure-hearted humans. If they succeed, they will be able to obtain the Holy Grail and use it to take over the entire world.
A young girl is attacked by a Daimon, but Serena is no longer able to transform into Sailor Moon, and the overpowered Sailor Team must one again rely on the mysterious new Sailor Scouts.
Serena's friend, Lizzy, is attacked by a Daimon and has her Pure Heart Crystal. After the crystal is dropped, Sailor Moon must race to find it and save Lizzy.
After Sailor Neptune is captured and possibly killed by Kaori Knight, Sailor Moon and Sailor Uranus find themselves shackled together and are forced to reassess their attitudes toward each tower.
Worried by Raye's increasingly intensive meditation, Chad becomes concerned that she has fallen for another man. When he sees with Amara, he is convinced that she is Raye's new suitor.
Serena is furious when Darien forgets her birthday. When Darien buys her an expensive pair of glass slippers to make up for it, he fails to realize that they have been implanted with a Daimon's Egg.
Serena and her friends are invited to a party for foreign university students, but her enthusiasm is tempered by the knowledge that most of the conversation will be in English.
Mina realizes that she is the only one of the Sailor Team not to have been targeted for her Pure Heart Crystal, and takes increasingly absurd measures to prove her purity.
Mimet infiltrates an idol competition in order to get close to her target, Jonah Araki. But when she qualifies for the final round, she considers quitting the Death Busters.
When Mimet decides to help in the production of a Daimon, she accidentally creates an anomaly that fractures the dimensions inside the Tomoe residence, trapping Rini and Hotaru.
After Hotaru and her father disappear from their house, the Sailor Scouts infiltrate Mugen Academy, suspicious that it is connected to the Death Busters.
Telulu opens a store selling Telluns, plants designed to remove Pure Heart Crystals. Meanwhile, Hotaru wakes up, confused, in the Messiah of Silence's chamber.
With the latest round of national Patrice exams being held at Mugen Academy, the Sailor Scouts infiltrate the school and Amy encounters her academic rival, Julie Bidou.
The Sailor Scouts approach Mugen Academy in order to save Rini and defeat the Death Busters, while Mistress 9 plans to steal the Holy Grail from Sailor Moon.
Mistress 9 steals the Holy Grail, allowing Pharaoh 90 to pass through the portal to Earth. The fate of the world rests in the hands of the Scout of Ruin, Sailor Saturn.
The Death Busters have been defeated, but Hotaru and Sailor Pluto's whereabouts are still unknown. Meanwhile, Amara and Michelle have one last mission before they leave Azabu-Juuban.