John Harmon, in Kansas City, writes Effie, his wife, to meet him in Chicago. At the same time, Trixie, an actress, leaves Kansas City for Chicago to meet her fiancé, John Courtney. On the train she hurts her finger opening the window and John Harmon binds it with his handkerchief. On arrival in Chicago, John engages rooms for himself and wife at the same hotel where Trixie puts up. Effie arrives to find her husband has been called back to Kansas City. She and Trixie become acquainted, and after the latter is called back to Kansas City by her fiancé, Effie, liking her new friend's room better, moves into it and finds her husband's handkerchief, also a telegram signed simply "John." In a jealous rage, she starts for Kansas City and when she locates her husband there are some tall doings. They visit Trixie and Courtney, the handkerchief incident is finally explained, then all become good friends.
—Moving Picture World synopsis