The investigation into the disappearance of a competitive eater turns up a reporter holding secrets about his past, a gambler trying to fix matches, and a prostitute and his dead pimp.
A water treatment plant supervisor disappears, and detectives discover that he is running from his old life in Arizona, where he may have been involved in a robbery and the disappearance of one of his friends.
A prominent congresswoman disappears on a boating trip, and is later found dead. The investigation suggests that it may be related to her vote on a controversial offshore drilling deal, but Jack is positive that her husband is involved.
A fifteen-year-old girl who is living with her grandfather disappears after last being seen at an Internet Cafe. Samantha's estranged sister makes an unexpected visit.
Sam's sister goes missing, so Sam decides to look for her without consulting with the rest of the team. Throughout her investigation, Sam's past unfolds.
The team searches for a stuntman who went missing shortly after completing a dangerous, fiery stunt. They discover that he received a death threat minutes before he vanished from the film set.
A girl disappears on prom night. Meanwhile, investigators discover that her drug-addicted boyfriend, believed to have been dead for months, may still be alive.
A Sudanese boy adopted by a high-profile New York couple disappears, and it is connected to a Sudanese man trying to extort the couple, claiming that he is the child's biological father.
A crime scene cleaner and his daughter are missing, and the case is connected to the daughter's possible sexual assault, and her self-esteem issues about being considered overweight.
A television reporter's disappearance is tied to her son's torture and death in a Guatemala prison. Jack is forced to bring in the CIA to help crack the case.
A young woman disappears after her boyfriend is killed in a police shooting. Agents believe the disappearance is connected to the girl's brother, a notorious gang leader who had a falling-out with her.
When a serial killer eludes capture in Nevada and escapes with his son to New York City, the crew picks up the trail with the help of Las Vegas CSI's Gil Grissom. Part two of a crossover with "CSI: Crime Scene Investigation."
A college student disappears after his racist statements are posted on an Internet video site, but the case reveals a secret about the student's racial identity and his real father.
While the team investigates the disappearance of an ex-con who served time for embezzlement, Agent Johnson gets a possible break in her case involving the kidnapping of a young woman.