Queen, blazes away at samurai on the Performance Floor with the special version of the Plague Rounds, which turns them into hideous ogres that corner Zoro and Drake.
King orders his subordinates to go after Momonosuke. Meanwhile, seeing people suffering from Queen's Plague Rounds, Chopper is determined to save everyone.
Yamato fights Sasaki and the Armored Division to protect Momonosuke. Meanwhile, Zoro tries to get rid of the Gifters who have turned into Ice Oni, but Queen starts a horrible game which involves the antibody for the virus.
Ulti and Page One of the Tobi Roppo chase Nami and Usopp, after being infuriated by their attack as well as Luffy's declaration of becoming the King of the Pirates. Cornered, Nami gives in and Ulti pushes her to say the unthinkable.
Carrot and Wanda step in to help Marco, who is cornered by Big Mom and Perospero. In the meantime, Yamato fights a fierce battle against the Animal Kingdom Pirates Armored Division led by Sasaki, while protecting Shinobu and Momonosuke.
Zoro and Drake continue to chase Apoo to get the antibody against Ice Oni, while Chopper is trying to figure out how to fight the virus. In the castle, Luffy, Jimbei, and Sanji are climbing up the stairs to reach the rooftop.
Yamato tells Momonosuke and Shinobu that she once confronted a man who came to Onigashima looking to get Kaido's head. His name was Ace. The two of them engaged in a fierce battle that eventually turned into an important friendship.
The formidable Lead Performers of the Animal Kingdom Pirates stand in Zoro's way as he tries to get to the rooftop. Marco sees his late comrade in Zoro's determination and tries to pave the way for him.
Luffy's strong attack reminds Kaido of all the strong ones he's ever met. On the other hand, Luffy, Law, and Kid keep quarrelling amongst themselves. Meanwhile, Sanji is caught and interrogated by Black Maria in what he calls "heaven."
Luffy, Law, Kid, Zoro, and Killer keep landing hard blows against Kaido in tandem despite the arguing. However, when Big Mom steps in and unleashes powerful lightning strikes, the tide turns for all except one of the rookies.
Luffy pummels Kaido with his Kong Gatling but uses up all of his strength. Big Mom tries to fight back, but Law gets in her way as Kid and Killer try to finish off Kaido.
Chopper works hard to make the cure for Ice Oni, even though he is turning into one himself. Meanwhile, the infected Boss Hyogoro the Flower regains his youth and fights fiercely to protect Chopper and the others.
Seeing everyone turning into Ice Oni, there is nothing that the samurai warriors can do but grieve. However, it wasn't just them devastated by Queen's raging virus. When their desperation and frustration peak, they hear a hopeful voice.
That unparalleled laugh. The Akazaya regain hope upon witnessing Oden's return. They failed in their attempt to take down Kaido, but after twenty years, they team up with Oden again to finish the job.
The Akazaya members run to save Momonosuke, but encounter a familiar enemy. Meanwhile, Kaido and Big Mom unleash a combination attack on the Supernovas.
Big Mom creates a replacement for Zeus and unleashes a tremendous attack on Kidd and Killer. Luffy vows to defeat Kaido after dealing a vicious blow to the Emperor.
As the Red Hair Pirates leave, Luffy promises Uta he will become stronger when she comes back. When Shanks returns without Uta some time later, Luffy feels betrayed.
Oden's samurai aim to stop Kanjuro while Yamato gives Oden's travel logs to Momonosuke. Luffy, Chopper and Sanji each continue fighting Kaido and his men. Ulti's actions cause Nami's rage to be heightened.
Luffy falls into the sea, with Kaido declaring a victory over him. Zeus is overwhelmed with emotion as he sees Big Mom has replaced him with Hera, leaving Zeus, seemingly, completely rejected by both Big Mom and Nami.
While the Straw Hats and their allies are all having a hard time, they are shocked by the news that Luffy lost to Kaido. At the same time, Kanjuro closes in on Momonosuke to destroy the Kozuki lineage.
Momonosuke and Shinobu face Kaido while Kid and Law challenge Big Mom. Meanwhile, Nami, heading towards the stage on the Performance Floor along with Usopp and Tama.
Nami strikes a thunder blast to clear the way to the stage on the Performance Floor. However, the elite corps of the Gifters show up to crush their inferior opponents. Upset but unbroken, Otama stands up to give a command.
The Gifters side with the samurai and upset the Tobi Roppo. Chopper starts to take care of Zoro while suffering from the side effect of the enhanced Rumble Ball. Meanwhile, Jimbei gets stunned by Who's-Who's story.
Who's-Who expresses fierce resentment toward Luffy and Jimbei fights back out of loyalty to his captain.. As Who's-Who asks Jimbei a question, he tramples on the dignity of the Fish-Men and that sparks Jimbei's outrage.
To cut ties with Kaido, Yamato unleashes his true power. Meanwhile, Queen repeatedly attacks Sanji with his power as a cyborg, and Sasaki in his Man-Beast Form launches tricky attacks on Franky and drives him into a corner.
Kaido tries to convince Yamato to become the Shogun of the Land of Wano and rule the country with the special power he obtained by accident. Meanwhile, Saul, Professor Clover, and Robin's mother Olvia suddenly appear in front of her.
In the dense mist, Brook is surprised to see his old friends, the Rumbar Pirates and Laboon. They reminisce about the old days and play music together, however, they suddenly attack Brook.
Black Maria torments Robin both physically and spiritually. As she burns in hellfire, Robin remembers the people who gave her a hard time and the people who supported her, and she as Demon Child shows what she is really capable of.
Killer is shocked to find out who Hawkins' straw doll he slashed represents. Meanwhile, Sanji who is in a hard battle against Queen and King sees enemy brutes going after the injured Zoro, and no one else is there to save him.
Zoro and Sanji look back on their friends' battles against the Tobi Roppo, the top officers of the Animal Kingdom Pirates. They describe how hard Nami, Robin, and the others fought to defeat the formidable enemies.