Ed Wright was played by Edward Mallory, who was the ex-husband of actress Joyce Bulifant, who married William Asher after he and Elizabeth Montgomery divorced.
The title refers to the Spanish-American War slogan "Remember the Maine!" that was cried after the sinking of the USS Maine in Havana harbor.
Samantha explains Charles Darwin's theory of evolution to her mother, albeit incorrectly. Dick York, who plays Samantha's husband, portrayed the Tennessee science teacher, John T. Scopes, who was prosecuted for teaching Darwin's theory in Inherit the Wind (1960).