This next to last Murder She Wrote story takes place in Atlanta where JB Fletcher is the guest at an amateur mystery writers convention. At the same hotel there's a bit of intrigue going on as a foreign agent is making a deal for some toxic viruses. Partly because an incriminating photograph was accidentally delivered to Angela Lansbury and partly because she knows the head of security at the Center For Disease Control Gregg Henry, Jessica Fletcher is hip deep in special ops.
Besides Henry also involved is the FBI William O'Leary, the NSC Tony Todd, and the CIA Peter Van Norden. All of them looking to close the case for their agency and all looking to show up the others.
It gets real serious when Henry is killed as well as one of the spies. With the assistance of the Atlanta PD in the person of Greg-Alan Williams JB Fletcher solves it and embarrasses the professionals. More than embarrasses one of them.