"Monkey See, Monkey Don't" was the first segment to be produced without John Kricfalusi's involvement, as he had been dismissed from the show late in the second season's production. It was produced by Games Animation (now known as Nickelodeon Animation Studio) and Billy West, already the voice of Stimpy, inherited the role of Ren.
The "monkey see, monkey don't" segment of the episode is banned on Paramount+.
"Monkey See, Monkey Don't" is the first segment episode where Billy West voices Ren, instead of John Kricfalusi who also got fired from the production of the second season and finished by Games Animation.