Chuckawalla is reputed as the "pizenest town that ever grew on a desert." It is near the Brent's Los Alamos ranch and its attractions for the cow-punchers are a constant source of trouble. Barbara sets out to "clean-up the town." She starts by buying the local paper and making herself editor. Then a red-hot campaign against the liquor interests, headed by the picturesque "Corn-juice," is set on foot. As the day of the local option election nears the opposition of the rough interests grows more and more desperate and Barbara is forced to the limit before a series of dramatic events results in victory for her cause and the removing of "the stain of Chuckawalla."
—Moving Picture World synopsis