Chris-Alice's name is a reference to chrysalis, which is a term in the cycle of butterflies and other insects.This is a reference to the personality of chris-alice which is immature
Vinnie, Creepie's adoptive father mosquito. It's a vegan originally was a stereotype of Dracula, but it was changed to an impression of Vincent Price in later episodes. His name is also a reference to the actor.
One of the main topics to be discussed in the series is how people treat people from different cultures and lifestyles badly, this was done through Creepie who must adapt to a life surrounded by a society of entomophobic humans, being part of from a different culture.
The design of the creepie eyes is different from that of the rest of the humans in the series, this is because the design of the same is inspired by the compound eyes of the invertebrates.
To design the mansion where Creepie and his family live, the team of creative directors will take several references from old hanna-barbera series such as Scooby-Doo and The Archie's in which the settings had tetric details.