This episode is notable for being one of the rare instances where Lupin and Fujiko are portrayed as being utterly despicable, cruel, and void of any redeemable character traits whatsoever. They are more closer to their manga counterparts.
The episode is adaptation of the New Lupin III / World's Most Wanted chapters Brain Swap
The blonde pin-up on Lupin's closet door bears a strong resemblance to Vivian from You're a Cat, I'm a Dried Bonito
The design of The Doctor is essentially a shaven version of Jigen's character model, with a few other cosmetic alterations.
Adapted from Chapters 80 and 81 of the second manga.