| Monica Calhoun | ... | Carol / ... (Episodes, 1989-1995) |
 | Tammy Lauren | ... | Elizabeth 'Lizzie' Stern / ... (Episodes, 1987-1993) |
| Nick Angotti | ... | Coach / ... (Episodes, 1986-1993) |
| Beau Dremann | ... | Beef / ... (Episodes, 1984-1988) |
| Vince Vaughn | ... | Richard / ... (Episodes, 1990-1991) |
| James Marshall | ... | Doug Simpson / ... (Episodes, 1986-1989) |
| Sean Le Sure | ... | Lonnie Jamal (Episodes, 1992-1995) |
| Dominic Oliver | ... | Paramédical / ... (Episodes, 1986-1990) |
| Khrystyne Haje | ... | Brianne Corey / ... (Episodes, 1986-1992) |
| Stephen Macht | ... | Bob Anastas / ... (Episodes, 1984-1987) |
| Josh Hamilton | ... | Chip Fulton / ... (Episodes, 1985-1991) |
| Peter Billingsley | ... | Joey Martelli / ... (Episodes, 1990-1994) |
| Justin Whalin | ... | Chaz Havelik / ... (Episodes, 1993) |
| George Dzundza | ... | Arthur Jennings / ... (Episodes, 1984-1988) |
| Bibi Besch | ... | Mrs. Evans / ... (Episodes, 1984) |
| Timothy Gibbs | ... | Jimmy Matthews / ... (Episodes, 1984) |
| Roxana Zal | ... | Allie Newton / ... (Episodes, 1986-1992) |
| Lori Loughlin | ... | Kelly / ... (Episodes, 1986-1988) |
| Karen Petrasek | ... | Farrah Bogdosian / ... (Episodes, 1985-1987) |
| Elinor Donahue | ... | Laura Donovan / ... (Episodes, 1984-1988) |
| Michael Durrell | ... | Lieutenant Gennaro / ... (Episodes, 1986-1993) |
| Allison Dean | ... | Kerry Cook / ... (Episodes, 1989-1990) |
| Claudia Wells | ... | Lisa / ... (Episodes, 1984-1986) |
| Millie Perkins | ... | Klara Markowitz / ... (Episodes, 1986-1994) |
| David Faustino | ... | Louie Dawson / ... (Episodes, 1986-1992) |
| Michael Landes | ... | David Corbin / ... (Episodes, 1992) |
| Christopher Collet | ... | Kyle / ... (Episodes, 1984-1991) |
| Geoffrey Blake | ... | Dexter Lee Smith / ... (Episodes, 1984-1989) |
| David Purdham | ... | Jimmy's Dad / ... (Episodes, 1990-1994) |
| Concetta Tomei | ... | Elizabeth Henderson (Episodes, 1990-1992) |
| Tito Ortiz | ... | TJ Tores / ... (Episodes, 1992-1993) |
| Johann Carlo | ... | Consuela Fabian / ... (Episodes, 1984-1985) |
| David Greenlee | ... | Gregg / ... (Episodes, 1985-1986) |
| Anne Meara | ... | Mrs. Salters / ... (Episodes, 1987-1993) |
| Darleen Carr | ... | Elanor Prosky / ... (Episodes, 1989-1993) |
| Marcelino Sánchez | ... | Jesse / ... (Episodes, 1985) |
| Michael Fairman | ... | Dr. Bolton / ... (Episodes, 1987-1989) |
| Manfred Melcher | ... | Bob / ... (Episodes, 1987-1988) |
| Alan Sader | ... | Dr. Hildebrand / ... (Episodes, 1988-1993) |
| J. Trevor Edmond | ... | Kevin (Episodes, 1990-1996) |
| Shirley Jo Finney | ... | Mrs. Jackson (Episodes, 1989-1992) |
| James Calvert | ... | Brian Lance / ... (Episodes, 1984-1992) |
| Fernando López | ... | Carter / ... (Episodes, 1991-1992) |
| Anne Gee Byrd | ... | Mrs. Shaw / ... (Episodes, 1984-1989) |
| Matthew Faison | ... | Kurt Green / ... (Episodes, 1987) |
| Danny Zorn | ... | Arnie Greenbaum / ... (Episodes, 1991-1992) |
| Alix Elias | ... | Aunt Magdelena / ... (Episodes, 1984-1994) |
| Lauren Woodland | ... | Cathy Fischer / ... (Episodes, 1987-1989) |
| Raymond Singer | ... | Arthur Katz / ... (Episodes, 1987-1988) |
| Ilario Pantano | ... | Mark (Episodes, 1994) |
| Israel Juarbe | ... | 2nd Piranha / ... (Episodes, 1984-1985) |
| R.D. Robb | ... | Jeremy / ... (Episodes, 1994-1995) |
| Nita Whitaker | ... | School Nurse (Episodes, 1990-1992) |
| Marty McGaw | ... | Fran Wisnewski / ... (Episodes, 1991-1993) |
| Charles Stransky | ... | Alfred Wainwright / ... (Episodes, 1989) |
| Kevin Sifuentes | ... | 1st Piranha / ... (Episodes, 1985-1989) |
| Holly Dorff | ... | Female Student / ... (Episodes, 1987-1989) |
| Gregory Paul Martin | ... | Brad / ... (Episodes, 1989-1990) |
| Gabriel Olds | ... | Richard (Episodes, 1992-1995) |
| Nicole Eggert | ... | Heidi (Episodes, 1984-1990) |
| Richard Moll | ... | Coach Hillman / ... (Episodes, 1992) |
| Gloria Carlin | ... | Frances Taylor / ... (Episodes, 1989-1993) |
