In Heart (2007), Sam beats Dean at Rock Paper Scissors and said "Oh, Dean, always with the scissors." While in the wall, AU Sam and Dean are playing RPS, and the second time Sam wins playing scissors and Dean paper. Then Dean tilts his head because Sam stole his move.
This was the last episode to air before the COVID-19 pandemic caused all TV and movie productions to halt and shutdown. Episodes resumed again in October, 2020.
During the scene where we get to know AU Sam and Dean and their world, the OG Winchesters--Sam, specifically--ask them to confirm that they have a private plane. AU Winchesters say that have two, to which OG Sam asks, with a hint of jealousy, "How do you afford it?" In real life, Jared Padalecki, who plays Sam, has a private jet of his own, which he often used to fly the cast in and out of Vancouver during their filming days for Supernatural (2005).
This marks the first time that Billie is featured in back to back episodes.