One of the first movies to use motion-capture in an on-location setting. Previously, motion-capture was limited to special studio set-up with special motion-capture cameras in very clearly defined surroundings.
Bright Eyes is given her "fizzy drink" in a Gatorade bottle because, during the research for the film, Director Rupert Wyatt learned that captive chimpanzees love sugar, and Gatorade is one of their favorite drinks.
There were long debates on whether or not Caesar should bite off Hunsiker's finger. Rupert Wyatt chose not to have the finger come off because he felt it would turn the audience against Caesar too much.
Caesar's speaking voice was produced by sound designer Chuck Michael, who mixed the sounds of fully grown male chimps' vocalizations recorded at Chimp Haven with Andy Serkis's voice.
When the apes climb the tree to escape the dome, they form a double helix, the shape of DNA and the Gen-Sys logo.
Karin Konoval: The stubborn court clerk that gave Will a hard time about filing for his appeal was played by Karin Konoval, who also played Maurice the orangutan. Director Rupert Wyatt brought her back after her ape performance capture to play a human because he liked her so much.
Terry Notary: The actor who plays Caesar's mother Bright Eyes and the former dominant chimpanzee Rocket also has an uncredited cameo as one of the gorillas on the Golden Gate Bridge action sequence.