First appearance of Dr. Arizona Robbins
It was Izzie's birthday in this episode. So that suggests that her birthday is on January 8th.
Every episode of the show is named after a famous song. "Wish You Were Here" is a song by Pink Floyd.
Eric Stolz (William Dunn) and Samantha Mathis (Melinda Prescott) previously starred together in the 1994 film 'Little Women'
Jessica Capshaw co-starred with Katherine Heigl in the 2001 movie "Valentine." Ironically, they never shared screen time together.