The idea for "The People in the Trees" is based on a true story from writer Eric Dickson's stay at an Airbnb in Atlanta, Georgia.
Cathy Podewell was the first cast member to sign on. After reading the script only once, she was quoted as saying, "Love the movie in a movie concept. Characters are great and I love Kim's character! It would be fun for me!"
Justin Dwayne Hall, who plays Perry in the film, is the Grandson of Fashion Designer, Sherri Hill.