- At therapy with Dr. Nolan, House tells about a cute amnesiac in ER, Wilson throwing him out and his old apartment being a mess after Alvarez broke in.
- During a session with Dr. Nolan, House recounts the case of a woman who arrives at the Princeton Plainsboro emergency room with an unexplained illness and no recollection of who she is. While trying to solve the mystery of the woman's illness, House must also help her piece together her identity.—Fox Publicity
- Open with House (Hugh Laurie) going to visit Dr. Nolan (Andre Braugher). He tells him about a recent case and it seems this episode will bounce back between the conversation and House telling him about a recent case.
A jogger is brought into the ER with no memory.
Nolan wants to know why House was in the ER to begin with House says Wilson (Robert Sean Leonard) recently asked him to move out since Sam (Cynthia Watros) is moving in. Nolan asks House whether he feels betrayed by Wilson. House said he's fine but Nolan doesn't believe him.
House suggests using the runner's heart rate monitor to find where she purchased the device where she might live.
Before work that day House returned to his old place and found Alvie (Lin-Manuel Miranda) had been staying there. He told Alvie not to be there when he got back from work.
Alvie did not leave so House let him stay and took him with him when he took the jogger to the store. No one recognized her at the store so House walks her around the neighborhood to see if anything looks familiar. During the walk Alvie tells House he's having immigration problems House gets the idea to take the jogger to the donut shop where they recognize her as "Sandy" or "Shelly." The guy she came with left a business card.
They visit the guy, her husband, and he calls her Sidney. She doesn't recognize the man (Jay), who tells Sidney she's a lawyer who runs to relieve stress. She doesn't think that sounds right.
House tells Nolan it was strange Sidney felt more comfortable with him than her husband.
Jay says Sidney just won a settlement for some people whose development was on a Methane field. She still can't believe they're married. On the way back to the hospital Sidney has incontinence and falls over. House tells Jay and Alvie she is having seizures.
Nolan points out House diagnosed her with something from his own medical history. He thinks House sees his past as a threat.
House buys back some of his stuff which Alvie pawned in order to buy point to update House's apartment. A book is missing.
House slams his fist on the table when Nolan continues to reference Wilson.
Cut to House and Alvie playing touch football in his apartment. Wilson knocks on the door to ask about him. After the game House tells Alvie he's set up an immigration hearing for him. Alvie's not interested. The phone rings with Taub (Peter Jacobson) saying that after 12 hours they have found no evidence of seizure.
House tells Nolan that Sidney had a "wake-up call" in college when her brother died. She then picked law school. Since she doesn't recall her brother's death, the cause of that change is gone.
Nolan points out Sidney is now irritated by Jay because he is forcing intimacy.
We see Sidney gasping for breath and being given oxygen. She has fluid in her lungs and the team gives her an MRI.
House tells Nolan he diagnosed Sidney with a kind of Encephalitis and had the team remove part of her brain. He doesn't know why House is telling him the specifics of her case. Nolan thinks this is part of House ignoring his own past and wonders why he should even listen to House if he doesn't see the link. Nolan begins reading a magazine and notices a bruise House got from a bar fight when he was blind drunk. House doesn't know why he's being getting drunk and Nolan thinks House is punishing himself by getting drunk and getting someone to hurt him. House finally admits "Okay, there may be a problem."
Wilson purchased House's stuff back for him and says he was hasty asking him to move out. House gets in his car and leaves in a huff.
House didn't think Wilson really meant the apology so it must have come from Cuddy (Lisa Edelstein). House guesses how the conversation between Wilson and Cuddy might have gone. House doesn't think either trusts him. Nolan suggests an alternative situation. Nolan asks why House and Wilson are friends. House says he feels he can say what he wants to Wilson and he'll never leave. Even now, House thinks Wilson will be back once he gets divorced from Sam again. Nolan still wants to know why House might want to punish himself and asks if other people were angry with him during the week,
Cut to Jay arguing with the doctors that Sidney shouldn't be allowed to consent for the surgery since there is a risk she could lose her memories. He argues she doesn't realize how important those memories are. House counters she could lose her whole brain without the surgery. Jay wants to know if there is any other way. At that moment House realizes the infection has spread and surgery is no longer an option. He bluntly tells Jay he "won," and his wife of four years has a few weeks left before she dies.
Nolan wonders why Jay made House so angry. House was bothered the husband was willing to risk his wife's life to save their marriage.
Cut to House trying to back the book Alvie pawned that had already been purchased. The guy who bought the book is a jerk in not selling it back to House. But Alvie actually stole the book while House was having the conversation.
Taub tells House whatever Sidney has is now attacking her entire body. At this point officers come in to deport Alvie for missing his hearing. Alvie turns to House "You called them?"
House gets updates from the team while sitting in a court room. House recommends a course of IV antibiotics and tells the team to isolate her in a room with AV light and get themselves tested since they've all been "exposed." House hands over fake DNA evidence to get Alvie off the hook.
At the hospital, House notices a tattoo on Sidney's ankle that was partially removed. The ink set off an allergic reaction when she started the ultra marathon running.
House tells Nolan Sidney still hadn't gotten her memory back, but we see Jay is now courting her. It was House's idea for him to treat her that way in order to win her back. Nolan thinks this week has been about relationships: One lost with Wilson and one gained with Alvie.
Cut to House returning home to find Alvie gone and a note on the table. House getting him out of trouble allowed him to safely go stay with a cousin in Phoenix. At this point House has some drinks and heads out the door for his eventual fight. House mentions Cuddy and Lucas are moving in together. Nolan jumps on his computer and finds out that the rare book Alvie stole back for House was written by Cuddy's great-grandfather and House had meant to give it to her at some point. Nolan thinks House identified with Jay when he was losing Sidney. House is upset at Nolan that for a year he's done what he was told to and now everyone around him is happy apart from House himself. House says "whatever the answer is, you don't have it," and leaves the office.
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