The two main characters, John Adams and Michael Ford, are voiced by William Morgan Sheppard and Mark Sheppard respectively, who are father and son in real life.
Actor Kevin Sorbo plays an Alien named Prometheus who is named after the Greek God who stole the "Flame" of knowledge from Mount Olympus and gave it to Humanity. This isn't the first time Sorbo played a Greek God, he played Hercules in the series "Hercules: The Legendary Journeys".