- Cesare Borgia: [to Cardinal Della Rovere, who has survived a poisoning] Don't worry. If you're not dead by now, you will live. Your tongue will be swollen for days... no talking. I'm afraid all your prayers must be silent ones.
- Cesare Borgia: [to a severely ill Della Rovere] The French army is ensnared in Naples. The French king is ill with the Neapolitan disease. God is in his Heaven, and the Pope on his seat in Rome... and my plea to you, Cardinal, is still the same. Work with us, not against us.
- Rodrigo Borgia: [to his quarreling sons] We are family, we are one, and we will only triumph as one.
- Cardinal Ascanio Sforza: The French ambassador waits, Holiness.
- Rodrigo Borgia: [Sarcastically] Isn't he dead yet?
- Cardinal Ascanio Sforza: He isn't even sick.
- Bianca: [as the Pope sensually bathes her] Will we meet again, Holy Father?
- Rodrigo Borgia: Perhaps.
- Bianca: Am I to be your mistress then?
- Rodrigo Borgia: Alas, no. That position is taken.