At the beginning of the episode when Sam is looking at Bobby's hunter's notebook, the last name listed at the bottom of the page is "Frank Furter," an allusion to the character Frank N. Furter from The Rocky Horror Picture Show.
When Dean expresses frustration over not knowing what's being built in the field, Frank says, "Patience, Grasshopper." He is quoting Master Po in the 1970s martial arts TV western, Kung Fu (1972). This is the second time Dean had been referred to as "Grasshopper", the first being called that by Alastair in On the Head of a Pin (2009).
Ian Tracey (Lee Chambers) also portrays the angel Ishim in the Season 12 episode, Lily Sunder Has Some Regrets (2017).
This episode title is the same as a 1987 movie starring Elisabeth Shue. It's about a babysitter who has to take the three kids she's watching into the city to rescue a friend and they end up being chased.
Meghan Ory previously acted alongside Jensen Ackles in the series Dark Angel (2000); the episode The Berrisford Agenda (2002).