Vicky Luengo (Antonia Scott) and Hovik Keuchkerian (Jon Gutiérrez) previously worked together on Antidisturbios (2020).
Filming started in Madrid on 16 August 2022, as shared by writer Juan Gómez-Jurado on Instagram.
On 19 March 2024, Director Koldo Serra confirmed on Instagram that Prime Video has commissioned Season 2 of Reina Roja: Loba Negra (second book of the Red Queen trilogy featuring Antonia Scott and Jon Gutiérrez).
The voiceovers and subtitles in English are from two different translations.