Leslie Hendrix, who plays the botanist who examines the yam, also played ME Rogers in many episodes of Law & Order (1990).
On the commentary Rob Schrab says that in the background of the scene where Jeff is getting a hot dog, there is a woman who comes out a door wiping her mouth, followed by a man doing up his zipper. Apparently, no one on the production knew about this, until people started making GIFs of it.
The episode's title "Basic Lupine Urology" is a reference to Dick Wolf, who developed Law & Order (1990).
Michael Kenneth Williams quotes his character Omar Little from the hit HBO show The Wire (2002), when he says "A man's gotta have a code"
Danny Pudi's children were born during the filming of this episode.