Corri English was chained to the chair for all twelve hours of filming one day and was so sore that she could barely move the next day.
The Fifty Shades of Grey joke was ad-libbed by Green and English.
Joe's line about the doctor not being "In Sane" while looking for Dr. Giggles was ad-libbed. The tagline for the movie "Dr Giggles" was "the Doctor Is In... Sane!"
Adam and Joe ad-libbed the bit where Adam is too short to see inside the hospital room window simply to make the crew laugh. The gag was kept in the final cut.
Series directors Adam Green and Sean Becker came up with the idea of naming the episode "Joe's Soda" while at a screening of "Ted" after a cast rehearsal. While discussing the joke about Joe's flat Diet Coke being the "A-Story Line" the two decided to actually name the episode "Joe's Soda" as well.