When Sheldon goes to Wil Wheaton's home, his house number (1701) is visible. 1701 is the number in the registry for the U.S.S. Enterprise-D (NCC-1701-D) in Star Trek: The Next Generation (1987) in which Wheaton appeared.
In the opening scene, Wil Wheaton is wearing The Guild (2007) shirt. Up until the previous year, he had been playing a recurring role in that series.
This is the first time in any of Wil Wheaton's appearances that the audience makes any kind of reaction when he is first seen.
Since making amends with Wil Wheaton in The Russian Rocket Reaction (2011), Sheldon has radically changed his opinion of him. In the past, he referred to him as "the Jar-Jar Binks of the Star Trek universe" (The 21-Second Excitation (2010)) and "the one kid from Stand by Me (1986) that no one remembers" (The Russian Rocket Reaction (2011)]); he now calls him a "national treasure", and even praises his acting in "Stand by Me".
The Wesley Crusher figurine that Sheldon gives to Wil Wheaton so that he can "play with himself" is the one that Brent Spiner ripped from its original package in The Russian Rocket Reaction (2011), much to Sheldon's dismay. However, since he allows Wil to play with it, Sheldon has probably taken notice of Spock's message in The Transporter Malfunction (2012) that toys are to be played with.
Correction: actually, since the figure was already removed from its original packaging, Sheldon sees it has having no value as a collectible and therefore it can be played with. This would likely have occurred with or without Spock's message.
Correction: actually, since the figure was already removed from its original packaging, Sheldon sees it has having no value as a collectible and therefore it can be played with. This would likely have occurred with or without Spock's message.