In chapter 11, once you watch the cutscenes (after leaving the tower), you can obtain a trophy called "Stage Fright" by standing still for 30 seconds. This is a humorous reference to Naughty Dogs technical problems when they first showed the scene on a live stage demo at E3.
Laura Bailey auditioned for and won the role of Nadine prior to the finalization of the character design. A concept artist later drew a piece of art with Nadine as a black character and director Neil Druckmann liked the idea of Nadine being a black character but feared inviting controversy having a white actress voice and perform a black character. It wasn't until Naughty Dog had seen Bailey's performance in context that they decided to keep Nadine as a black character as it "vanished into the part and you didn't see anything but Nadine".
In Chapter 4, there is a box that has a sticky note that says "send to Marissa", in the attic. This is a nod to Uncharted Golden Abyss, Marissa Chase, Nates ally in that game
There are three "Strange Relics" that can be found in the game, each referencing Naughty Dog's three other Playstation game series. The Strange Pendant is a Firefly pendant from The Last of Us, the Strange Relic is a precursor orb from Jak and Daxter, and the Strange Fruit is a wumpa fruit from Crash Bandicoot.
Sold over 2.7 million copies during its first week of release.