Nikki makes sexting classier, quizzes her guests on the latest developments in the erotic sciences and hosts a game show to help strip club patrons win their money back.
Nikki weighs the pros and cons of sexting with T.J. Miller and Pete Holmes, considers entering into an open relationship and tries out a marijuana-infused lubricant.
Nikki attends a class on cuddling, plays Tinder Tapout with Adam Pally and Mary Lynn Rajskub, and gets to the bottom of why more women are getting labiaplasties.
Nikki teams up with Kristen Schaal to provide dialogue for a porn scene, plays Sext Symbols with Chris D'Elia and Kate Walsh, and quizzes strip club patrons about women.
Nikki sticks it to the judge of the Stanford rape case, helps Omarion produce a song about awkward sex, and plays What's Your Number? with Riki Lindhome and Anthony Jeselnik.
Nikki volunteers for an orgasm study, plays I Come Bearing GIFs with Liza Treyger and Jim Jefferies, and interviews people about where they prefer to finish after sex.
Nikki delves into the topic of the popularity of over-the-counter male enhancement pills with Dr. Drew Pinsky; helps unmarried couples write their prenups.
Nikki provides the dialogue for a hospital porn scene, calls out annoying behavior on social media with her guests and works with couples to plan for their eventual breakup.
Nikki visits a museum full of people's old relationship keepsakes, debunks myths about bisexuals with Margaret Cho and rails against the injustices of America's wage gap.
Nikki heads to Las Vegas to make an attempt at spending 24 hours in a strip club; Jim Norton and Bridget Everett join Nikki for a round of Tinder Tapout.