The photograph in the locket that the fictional Lizzie's father gives her is of the real Lizzie Borden's mother Sarah. She died when Lizzie was a baby.
This project was in development for many years as a passion project of Chloë Sevigny's. At one point it was set up at HBO as a miniseries, until a rival project from another studio caused HBO to axe the project. Sevigny and writer Bryce Kass then bought the rights back to the project.
Apart from Lizzie Borden, Bridget Sullivan, Emma Borden, and John Morse have also been speculated to be suspects in the murders.
It was filmed in 23 days.
Filming for "Lizzie" took place in November and December 2016. The filming location was Savannah, Georgia.